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Interaction potential of the multitargeted receptor tyrosine kinase inhibitor dovitinib with drug transporters and drug metabolising enzymes assessed in vitro

Dovitinib (TKI-258) is under development for the treatment of diverse cancer entities. No published information on its pharmacokinetic drug interaction potential is available. Thus, we assessed its interaction with important drug metabolising enzymes and drug transporters and its efficacy in multidr...

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Main Authors: Weiß, Johanna (Author) , Theile, Dirk (Author) , Dvorak, Zdenek (Author) , Haefeli, Walter E. (Author)
Format: Article (Journal)
Language:English
Published: 16 December 2014
In: Pharmaceutics
Year: 2014, Volume: 6, Issue: 4, Pages: 632-650
ISSN:1999-4923
DOI:10.3390/pharmaceutics6040632
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3390/pharmaceutics6040632
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1999-4923/6/4/632
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Author Notes:Johanna Weiss, Dirk Theile, Zdenek Dvorak and Walter Emil Haefeli

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