Baseline anti-dsDNA concentrations and previous treatments predict response to Adalimumab and Etanercept: a retrospective investigation of 146 psoriasis patients
Background - Adalimumab and Etanercept are TNF-α antagonists commonly used for treatment of moderate-to-severe psoriasis and psoriatic-arthritis. Reliable instruments to assist the selection of patients for a specific treatment in a real-world scenario are unavailable. - Objective - To identify pati...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 September 2014
|
| In: |
Journal of dermatological science
Year: 2014, Jahrgang: 76, Heft: 3, Pages: 180-185 |
| ISSN: | 1873-569X |
| DOI: | 10.1016/j.jdermsci.2014.09.003 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jdermsci.2014.09.003 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0923181114002205 
|
| Verfasserangaben: | Jochen H.O. Hoffmann, Christian Knoop, Alexander H. Enk, Eva N. Hadaschik |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1736072889 | ||
| 003 | DE-627 | ||
| 005 | 20240926090937.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201021s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jdermsci.2014.09.003 |2 doi | |
| 035 | |a (DE-627)1736072889 | ||
| 035 | |a (DE-599)KXP1736072889 | ||
| 035 | |a (OCoLC)1341372975 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hoffmann, Jochen |e VerfasserIn |0 (DE-588)1074973267 |0 (DE-627)832794430 |0 (DE-576)443176698 |4 aut | |
| 245 | 1 | 0 | |a Baseline anti-dsDNA concentrations and previous treatments predict response to Adalimumab and Etanercept |b a retrospective investigation of 146 psoriasis patients |c Jochen H.O. Hoffmann, Christian Knoop, Alexander H. Enk, Eva N. Hadaschik |
| 264 | 1 | |c 28 September 2014 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.10.2020 | ||
| 520 | |a Background - Adalimumab and Etanercept are TNF-α antagonists commonly used for treatment of moderate-to-severe psoriasis and psoriatic-arthritis. Reliable instruments to assist the selection of patients for a specific treatment in a real-world scenario are unavailable. - Objective - To identify patient characteristics and baseline laboratory parameters predicting response to Adalimumab- and Etanercept-treatment. - Methods - We report a retrospective observational study including 116 and 64 psoriasis-patients treated with Adalimumab and Etanercept, respectively, at a dermatological outpatient clinic of a university hospital. Thirty four patients contributed data to both biologics. First occurrence of either loss-of-response or serious-side-effects (LOR/SSE) was chosen as clinical endpoint and predictors were identified using Cox-regression. - Results - Baseline anti-double-stranded DNA (anti-dsDNA) concentrations, number of previous treatments with TNF-α antagonists in general and previous treatment with Etanercept in particular significantly predicted LOR/SSE to Adalimumab. The predictive effect of baseline anti-dsDNA was conserved in TNF-α antagonist naïve patients. Number of previous systemic treatments other than TNF-α antagonists significantly predicted LOR/SSE to Etanercept. Age and baseline psoriasis area and severity index (PASI) did not predict response to either biologic in a clinically significant manner. - Conclusion - Our data suggests that treatment with Adalimumab may promise best results in psoriasis-patients with (A) low baseline anti-dsDNA concentrations, and (B) no previous TNF-α antagonist treatment. A clinically significant predictive effect of age and baseline PASI on response to Adalimumab and Etanercept is unlikely. | ||
| 650 | 4 | |a Autoantibodies | |
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Psoriasis | |
| 650 | 4 | |a TNF-α antagonist | |
| 700 | 1 | |a Knoop, Christian |d 1985- |e VerfasserIn |0 (DE-588)1077455364 |0 (DE-627)836709748 |0 (DE-576)446287903 |4 aut | |
| 700 | 1 | |a Enk, Alexander |d 1963- |e VerfasserIn |0 (DE-588)1032757140 |0 (DE-627)739272535 |0 (DE-576)166173517 |4 aut | |
| 700 | 1 | |a Hadaschik, Eva |e VerfasserIn |0 (DE-588)1054876916 |0 (DE-627)792376684 |0 (DE-576)410969842 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of dermatological science |d Amsterdam [u.a.] : Elsevier Science, 1990 |g 76(2014), 3, Seite 180-185 |h Online-Ressource |w (DE-627)323606431 |w (DE-600)2026237-1 |w (DE-576)095238042 |x 1873-569X |7 nnas |a Baseline anti-dsDNA concentrations and previous treatments predict response to Adalimumab and Etanercept a retrospective investigation of 146 psoriasis patients |
| 773 | 1 | 8 | |g volume:76 |g year:2014 |g number:3 |g pages:180-185 |g extent:6 |a Baseline anti-dsDNA concentrations and previous treatments predict response to Adalimumab and Etanercept a retrospective investigation of 146 psoriasis patients |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jdermsci.2014.09.003 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0923181114002205 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201021 | ||
| 993 | |a Article | ||
| 994 | |a 2014 | ||
| 998 | |g 1054876916 |a Hadaschik, Eva |m 1054876916:Hadaschik, Eva |d 910000 |d 911300 |d 50000 |e 910000PH1054876916 |e 911300PH1054876916 |e 50000PH1054876916 |k 0/910000/ |k 1/910000/911300/ |k 0/50000/ |p 4 |y j | ||
| 998 | |g 1032757140 |a Enk, Alexander |m 1032757140:Enk, Alexander |d 910000 |d 911300 |e 910000PE1032757140 |e 911300PE1032757140 |k 0/910000/ |k 1/910000/911300/ |p 3 | ||
| 998 | |g 1074973267 |a Hoffmann, Jochen |m 1074973267:Hoffmann, Jochen |d 910000 |d 911300 |e 910000PH1074973267 |e 911300PH1074973267 |k 0/910000/ |k 1/910000/911300/ |p 1 |x j | ||
| 999 | |a KXP-PPN1736072889 |e 3783486343 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Jochen H.O. Hoffmann, Christian Knoop, Alexander H. Enk, Eva N. Hadaschik"]},"physDesc":[{"extent":"6 S."}],"relHost":[{"id":{"issn":["1873-569X"],"eki":["323606431"],"zdb":["2026237-1"]},"language":["eng"],"disp":"Baseline anti-dsDNA concentrations and previous treatments predict response to Adalimumab and Etanercept a retrospective investigation of 146 psoriasis patientsJournal of dermatological science","recId":"323606431","title":[{"subtitle":"the official journal of the Japanese Society for Investigative Dermatology","title":"Journal of dermatological science","title_sort":"Journal of dermatological science"}],"part":{"pages":"180-185","issue":"3","extent":"6","text":"76(2014), 3, Seite 180-185","year":"2014","volume":"76"},"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"1990-","dateIssuedKey":"1990","publisher":"Elsevier Science","publisherPlace":"Amsterdam [u.a.]"}],"note":["Gesehen am 18.02.2020"],"pubHistory":["1.1990 -"],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 21.10.2020"],"origin":[{"dateIssuedKey":"2014","dateIssuedDisp":"28 September 2014"}],"title":[{"subtitle":"a retrospective investigation of 146 psoriasis patients","title":"Baseline anti-dsDNA concentrations and previous treatments predict response to Adalimumab and Etanercept","title_sort":"Baseline anti-dsDNA concentrations and previous treatments predict response to Adalimumab and Etanercept"}],"language":["eng"],"id":{"doi":["10.1016/j.jdermsci.2014.09.003"],"eki":["1736072889"]},"recId":"1736072889","person":[{"role":"aut","family":"Hoffmann","display":"Hoffmann, Jochen","roleDisplay":"VerfasserIn","given":"Jochen"},{"family":"Knoop","role":"aut","given":"Christian","roleDisplay":"VerfasserIn","display":"Knoop, Christian"},{"display":"Enk, Alexander","roleDisplay":"VerfasserIn","given":"Alexander","role":"aut","family":"Enk"},{"display":"Hadaschik, Eva","given":"Eva","roleDisplay":"VerfasserIn","role":"aut","family":"Hadaschik"}]} | ||
| SRT | |a HOFFMANNJOBASELINEAN2820 | ||