The MELD score predicts the short-term and overall survival after liver transplantation in patients with primary sclerosing cholangitis or autoimmune liver diseases
Purpose: Liver transplantation (LT) is well established in patients with autoimmune liver disease. Despite excellent outcomes, organ scarcity demands careful patients’ selection and timing of transplantation. Methods: This retrospective study analyzes data of 79 consecutive patients with primary scl...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
09 August 2014
|
| In: |
Langenbeck's archives of surgery
Year: 2014, Volume: 399, Issue: 8, Pages: 1001-1009 |
| ISSN: | 1435-2451 |
| DOI: | 10.1007/s00423-014-1237-z |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00423-014-1237-z
|
| Author Notes: | Katrin Hoffmann, Ulf Hinz, Norbert Hillebrand, Tom Ganten, Daniel Gotthardt, Thomas Longerich, Peter Schirmacher, Peter Schemmer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1736073915 | ||
| 003 | DE-627 | ||
| 005 | 20220818233409.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201021s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00423-014-1237-z |2 doi | |
| 035 | |a (DE-627)1736073915 | ||
| 035 | |a (DE-599)KXP1736073915 | ||
| 035 | |a (OCoLC)1341372935 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hoffmann, Katrin |d 1980- |e VerfasserIn |0 (DE-588)131774417 |0 (DE-627)513946950 |0 (DE-576)252913078 |4 aut | |
| 245 | 1 | 4 | |a The MELD score predicts the short-term and overall survival after liver transplantation in patients with primary sclerosing cholangitis or autoimmune liver diseases |c Katrin Hoffmann, Ulf Hinz, Norbert Hillebrand, Tom Ganten, Daniel Gotthardt, Thomas Longerich, Peter Schirmacher, Peter Schemmer |
| 264 | 1 | |c 09 August 2014 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.10.2020 | ||
| 520 | |a Purpose: Liver transplantation (LT) is well established in patients with autoimmune liver disease. Despite excellent outcomes, organ scarcity demands careful patients’ selection and timing of transplantation. Methods: This retrospective study analyzes data of 79 consecutive patients with primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH), and overlap syndrome, undergoing LT between 2001 and 2012. Overall survival (OS) and graft survival were assessed using Kaplan-Meier estimate. Multivariate survival analysis was performed to identify prognostic factors by using Cox regression model. Results: After 59.6-month median follow-up, the 5-year OS and graft survival were 75.3 and 68.8 %, respectively. The 5-year survival rates for patients with PSC (n = 57), AIH (n = 17), and overlap syndrome (n = 5) were 76.3, 76.0, and 60.0 %. The 90-day mortality rate of 70.0 % was significantly higher in patients with a labMELD score ≥20 (n = 10) compared to 26.1 % in 69 patients with a labMELD <20 (p = 0.009). A lab Model for End-Stage Liver Disease (MELD) score ≥20 was an independent predictor of impaired OS (p = 0.050, hazard ratio 2.5). The 5-year OS was 55.7 % in patients with a labMELD score ≥20 compared to 84.7 % in patients with a labMELD score <20.Conclusion: The recipients’ MELD score is a predictor for the short-term outcome after LT in patients with autoimmune liver disease. Meticulous selection for transplant listing remains necessary to safe scarce donor organs. | ||
| 700 | 1 | |a Hinz, Ulf |e VerfasserIn |0 (DE-588)1022150499 |0 (DE-627)716927748 |0 (DE-576)175505284 |4 aut | |
| 700 | 1 | |a Ganten, Tom M. |d 1969- |e VerfasserIn |0 (DE-588)115539670 |0 (DE-627)69139010X |0 (DE-576)289938899 |4 aut | |
| 700 | 1 | |a Gotthardt, Daniel |d 1973- |e VerfasserIn |0 (DE-588)12903293X |0 (DE-627)387885137 |0 (DE-576)297458027 |4 aut | |
| 700 | 1 | |a Longerich, Thomas |d 1974- |e VerfasserIn |0 (DE-588)128494514 |0 (DE-627)373916124 |0 (DE-576)297178059 |4 aut | |
| 700 | 1 | |a Schirmacher, Peter |d 1961- |e VerfasserIn |0 (DE-588)1020440112 |0 (DE-627)691221197 |0 (DE-576)360427448 |4 aut | |
| 700 | 1 | |a Schemmer, Peter |d 1967- |e VerfasserIn |0 (DE-588)1022604244 |0 (DE-627)717006794 |0 (DE-576)365668230 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Langenbeck's archives of surgery |d Berlin : Springer, 1998 |g 399(2014), 8, Seite 1001-1009 |h Online-Ressource |w (DE-627)253770440 |w (DE-600)1459390-7 |w (DE-576)072578564 |x 1435-2451 |7 nnas |a The MELD score predicts the short-term and overall survival after liver transplantation in patients with primary sclerosing cholangitis or autoimmune liver diseases |
| 773 | 1 | 8 | |g volume:399 |g year:2014 |g number:8 |g pages:1001-1009 |g extent:9 |a The MELD score predicts the short-term and overall survival after liver transplantation in patients with primary sclerosing cholangitis or autoimmune liver diseases |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00423-014-1237-z |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201021 | ||
| 993 | |a Article | ||
| 994 | |a 2014 | ||
| 998 | |g 1022604244 |a Schemmer, Peter |m 1022604244:Schemmer, Peter |d 910000 |d 912000 |d 50000 |e 910000PS1022604244 |e 912000PS1022604244 |e 50000PS1022604244 |k 0/910000/ |k 1/910000/912000/ |k 0/50000/ |p 8 |y j | ||
| 998 | |g 1020440112 |a Schirmacher, Peter |m 1020440112:Schirmacher, Peter |d 910000 |d 912000 |e 910000PS1020440112 |e 912000PS1020440112 |k 0/910000/ |k 1/910000/912000/ |p 7 | ||
| 998 | |g 128494514 |a Longerich, Thomas |m 128494514:Longerich, Thomas |d 910000 |d 912000 |e 910000PL128494514 |e 912000PL128494514 |k 0/910000/ |k 1/910000/912000/ |p 6 | ||
| 998 | |g 12903293X |a Gotthardt, Daniel |m 12903293X:Gotthardt, Daniel |d 910000 |d 910100 |d 50000 |e 910000PG12903293X |e 910100PG12903293X |e 50000PG12903293X |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 5 | ||
| 998 | |g 115539670 |a Ganten, Tom M. |m 115539670:Ganten, Tom M. |d 50000 |e 50000PG115539670 |k 0/50000/ |p 4 | ||
| 998 | |g 1022150499 |a Hinz, Ulf |m 1022150499:Hinz, Ulf |d 910000 |d 910200 |e 910000PH1022150499 |e 910200PH1022150499 |k 0/910000/ |k 1/910000/910200/ |p 2 | ||
| 998 | |g 131774417 |a Hoffmann, Katrin |m 131774417:Hoffmann, Katrin |d 910000 |d 910200 |d 50000 |e 910000PH131774417 |e 910200PH131774417 |e 50000PH131774417 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1736073915 |e 3783488923 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 21.10.2020"],"relHost":[{"disp":"The MELD score predicts the short-term and overall survival after liver transplantation in patients with primary sclerosing cholangitis or autoimmune liver diseasesLangenbeck's archives of surgery","recId":"253770440","part":{"extent":"9","text":"399(2014), 8, Seite 1001-1009","pages":"1001-1009","volume":"399","issue":"8","year":"2014"},"origin":[{"publisherPlace":"Berlin ; Heidelberg","dateIssuedDisp":"1998-","publisher":"Springer","dateIssuedKey":"1998"}],"id":{"zdb":["1459390-7"],"issn":["1435-2451"],"eki":["253770440"]},"pubHistory":["Volume 383, issue 1 (March 1998)-"],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 24.03.25","Teils ungezählte Beil.: Supplement"],"corporate":[{"role":"isb","display":"Deutsche Gesellschaft für Chirurgie"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title_sort":"Langenbeck's archives of surgery","title":"Langenbeck's archives of surgery","subtitle":"continues Langenbecks Archiv für Chirurgie : organ of the congresses of the German Society of Surgery : official journal of the German Association of Endocrine Surgeons, affiliated to the German Society of Surgery"}]}],"person":[{"display":"Hoffmann, Katrin","family":"Hoffmann","role":"aut","given":"Katrin"},{"role":"aut","given":"Ulf","family":"Hinz","display":"Hinz, Ulf"},{"display":"Ganten, Tom M.","role":"aut","given":"Tom M.","family":"Ganten"},{"display":"Gotthardt, Daniel","role":"aut","given":"Daniel","family":"Gotthardt"},{"display":"Longerich, Thomas","family":"Longerich","given":"Thomas","role":"aut"},{"display":"Schirmacher, Peter","role":"aut","given":"Peter","family":"Schirmacher"},{"role":"aut","given":"Peter","family":"Schemmer","display":"Schemmer, Peter"}],"title":[{"title_sort":"MELD score predicts the short-term and overall survival after liver transplantation in patients with primary sclerosing cholangitis or autoimmune liver diseases","title":"The MELD score predicts the short-term and overall survival after liver transplantation in patients with primary sclerosing cholangitis or autoimmune liver diseases"}],"language":["eng"],"physDesc":[{"extent":"9 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1736073915"],"doi":["10.1007/s00423-014-1237-z"]},"origin":[{"dateIssuedKey":"2014","dateIssuedDisp":"09 August 2014"}],"name":{"displayForm":["Katrin Hoffmann, Ulf Hinz, Norbert Hillebrand, Tom Ganten, Daniel Gotthardt, Thomas Longerich, Peter Schirmacher, Peter Schemmer"]},"recId":"1736073915"} | ||
| SRT | |a HOFFMANNKAMELDSCOREP0920 | ||