Expression of M2 macrophage markers YKL-39 and CCL18 in breast cancer is associated with the effect of neoadjuvant chemotherapy
High activity of enzyme TOP2a in tumor cells is known to be associated with sensitivity to anthracycline chemotherapy, but 20% of such patients do not show clinical response. Tumor microenvironment, including tumor-associated macrophages (TAM), is an essential factor defining the efficiency of chemo...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
4 May 2018
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| In: |
Cancer chemotherapy and pharmacology
Year: 2018, Volume: 82, Issue: 1, Pages: 99-109 |
| ISSN: | 1432-0843 |
| DOI: | 10.1007/s00280-018-3594-8 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00280-018-3594-8
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| Author Notes: | Nikolai Litviakov, Matvey Tsyganov, Irina Larionova, Marina Ibragimova, Irina Deryusheva, Polina Kazantseva, Elena Slonimskaya, Irina Frolova, Eugeniy Choinzonov, Nadezhda Cherdyntseva, Julia Kzhyshkowska |
| Summary: | High activity of enzyme TOP2a in tumor cells is known to be associated with sensitivity to anthracycline chemotherapy, but 20% of such patients do not show clinical response. Tumor microenvironment, including tumor-associated macrophages (TAM), is an essential factor defining the efficiency of chemotherapy. In the present study, we analyzed the expression of M2 macrophage markers, YKL-39 and CCL18, in tumors of breast cancer patients received anthracycline-based NAC. |
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| Item Description: | Gesehen am 22.10.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1432-0843 |
| DOI: | 10.1007/s00280-018-3594-8 |