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Selenium deficiency is associated with mortality risk from COVID-19

SARS-CoV-2 infections underlie the current coronavirus disease (COVID-19) pandemic and are causative for a high death toll particularly among elderly subjects and those with comorbidities. Selenium (Se) is an essential trace element of high importance for human health and particularly for a well-bal...

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Hauptverfasser: Moghaddam-Alvandi, Arash (VerfasserIn) , Heller, Raban (VerfasserIn) , Sun, Qian (VerfasserIn) , Seelig, Julian (VerfasserIn) , Cherkezov, Asan (VerfasserIn) , Seibert, Linda (VerfasserIn) , Hackler, Julian (VerfasserIn) , Seemann, Petra (VerfasserIn) , Diegmann, Joachim (VerfasserIn) , Pilz, Maximilian (VerfasserIn) , Bachmann, Manuel (VerfasserIn) , Minich, Waldemar B. (VerfasserIn) , Schomburg, Lutz (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 16 July 2020
In: Nutrients
Year: 2020, Jahrgang: 12, Heft: 7, Pages: 2098
ISSN:2072-6643
DOI:10.3390/nu12072098
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/nu12072098
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6643/12/7/2098
Volltext
Verfasserangaben:Arash Moghaddam, Raban Arved Heller, Qian Sun, Julian Seelig, Asan Cherkezov, Linda Seibert, Julian Hackler, Petra Seemann, Joachim Diegmann, Maximilian Pilz, Manuel Bachmann, Waldemar B. Minich and Lutz Schomburg
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Zusammenfassung:SARS-CoV-2 infections underlie the current coronavirus disease (COVID-19) pandemic and are causative for a high death toll particularly among elderly subjects and those with comorbidities. Selenium (Se) is an essential trace element of high importance for human health and particularly for a well-balanced immune response. The mortality risk from a severe disease like sepsis or polytrauma is inversely related to Se status. We hypothesized that this relation also applies to COVID-19. Serum samples (n = 166) from COVID-19 patients (n = 33) were collected consecutively and analyzed for total Se by X-ray fluorescence and selenoprotein P (SELENOP) by a validated ELISA. Both biomarkers showed the expected strong correlation (r = 0.7758, p < 0.001), pointing to an insufficient Se availability for optimal selenoprotein expression. In comparison with reference data from a European cross-sectional analysis (EPIC, n = 1915), the patients showed a pronounced deficit in total serum Se (mean &plusmn; SD, 50.8 &plusmn; 15.7 vs. 84.4 &plusmn; 23.4 &micro;g/L) and SELENOP (3.0 &plusmn; 1.4 vs. 4.3 &plusmn; 1.0 mg/L) concentrations. A Se status below the 2.5th percentile of the reference population, i.e., [Se] < 45.7 &micro;g/L and [SELENOP] < 2.56 mg/L, was present in 43.4% and 39.2% of COVID samples, respectively. The Se status was significantly higher in samples from surviving COVID patients as compared with non-survivors (Se; 53.3 &plusmn; 16.2 vs. 40.8 &plusmn; 8.1 &micro;g/L, SELENOP; 3.3 &plusmn; 1.3 vs. 2.1 &plusmn; 0.9 mg/L), recovering with time in survivors while remaining low or even declining in non-survivors. We conclude that Se status analysis in COVID patients provides diagnostic information. However, causality remains unknown due to the observational nature of this study. Nevertheless, the findings strengthen the notion of a relevant role of Se for COVID convalescence and support the discussion on adjuvant Se supplementation in severely diseased and Se-deficient patients.
Beschreibung:Gesehen am 22.10.2020
Beschreibung:Online Resource
ISSN:2072-6643
DOI:10.3390/nu12072098

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