Selenium deficiency is associated with mortality risk from COVID-19
SARS-CoV-2 infections underlie the current coronavirus disease (COVID-19) pandemic and are causative for a high death toll particularly among elderly subjects and those with comorbidities. Selenium (Se) is an essential trace element of high importance for human health and particularly for a well-bal...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 July 2020
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| In: |
Nutrients
Year: 2020, Jahrgang: 12, Heft: 7, Pages: 2098 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12072098 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/nu12072098 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6643/12/7/2098 
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| Verfasserangaben: | Arash Moghaddam, Raban Arved Heller, Qian Sun, Julian Seelig, Asan Cherkezov, Linda Seibert, Julian Hackler, Petra Seemann, Joachim Diegmann, Maximilian Pilz, Manuel Bachmann, Waldemar B. Minich and Lutz Schomburg |
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| 245 | 1 | 0 | |a Selenium deficiency is associated with mortality risk from COVID-19 |c Arash Moghaddam, Raban Arved Heller, Qian Sun, Julian Seelig, Asan Cherkezov, Linda Seibert, Julian Hackler, Petra Seemann, Joachim Diegmann, Maximilian Pilz, Manuel Bachmann, Waldemar B. Minich and Lutz Schomburg |
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| 520 | |a SARS-CoV-2 infections underlie the current coronavirus disease (COVID-19) pandemic and are causative for a high death toll particularly among elderly subjects and those with comorbidities. Selenium (Se) is an essential trace element of high importance for human health and particularly for a well-balanced immune response. The mortality risk from a severe disease like sepsis or polytrauma is inversely related to Se status. We hypothesized that this relation also applies to COVID-19. Serum samples (n = 166) from COVID-19 patients (n = 33) were collected consecutively and analyzed for total Se by X-ray fluorescence and selenoprotein P (SELENOP) by a validated ELISA. Both biomarkers showed the expected strong correlation (r = 0.7758, p < 0.001), pointing to an insufficient Se availability for optimal selenoprotein expression. In comparison with reference data from a European cross-sectional analysis (EPIC, n = 1915), the patients showed a pronounced deficit in total serum Se (mean ± SD, 50.8 ± 15.7 vs. 84.4 ± 23.4 µg/L) and SELENOP (3.0 ± 1.4 vs. 4.3 ± 1.0 mg/L) concentrations. A Se status below the 2.5th percentile of the reference population, i.e., [Se] < 45.7 µg/L and [SELENOP] < 2.56 mg/L, was present in 43.4% and 39.2% of COVID samples, respectively. The Se status was significantly higher in samples from surviving COVID patients as compared with non-survivors (Se; 53.3 ± 16.2 vs. 40.8 ± 8.1 µg/L, SELENOP; 3.3 ± 1.3 vs. 2.1 ± 0.9 mg/L), recovering with time in survivors while remaining low or even declining in non-survivors. We conclude that Se status analysis in COVID patients provides diagnostic information. However, causality remains unknown due to the observational nature of this study. Nevertheless, the findings strengthen the notion of a relevant role of Se for COVID convalescence and support the discussion on adjuvant Se supplementation in severely diseased and Se-deficient patients. | ||
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