Reduced intensity-conditioned allogeneic stem cell transplantation for multiple myeloma relapsing or progressing after autologous transplantation: a study by the European Group for Blood and Marrow Transplantation
Outcomes and prognostic factors of reduced intensity-conditioned allo-SCT (RIC allo-SCT) for multiple myeloma (MM) relapsing or progressing after prior autologous (auto)-SCT are not well defined. We performed an analysis of 413 MM patients who received a related or unrelated RIC allo-SCT for the tre...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 May 2013
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| In: |
Bone marrow transplantation
Year: 2013, Jahrgang: 48, Heft: 11, Pages: 1395-1400 |
| ISSN: | 1476-5365 |
| DOI: | 10.1038/bmt.2013.73 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/bmt.2013.73 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/bmt201373 
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| Verfasserangaben: | HW Auner, R Szydlo, A van Biezen, S Iacobelli, G Gahrton, N Milpied, L Volin, J Janssen, S Nguyen Quoc, M Michallet, H Schoemans, J el Cheikh, E Petersen, F Guilhot, S Schönland, L Ahlberg, C Morris, L Garderet, T de Witte and N Kröger, on behalf of the plasma cell dyscrasia sub-committee of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation (EBMT) |
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| 520 | |a Outcomes and prognostic factors of reduced intensity-conditioned allo-SCT (RIC allo-SCT) for multiple myeloma (MM) relapsing or progressing after prior autologous (auto)-SCT are not well defined. We performed an analysis of 413 MM patients who received a related or unrelated RIC allo-SCT for the treatment of relapse/progression after prior auto-SCT. Median age at RIC allo-SCT was 54.1 years, and 44.6% of patients had undergone two or more prior auto-SCTs. Median OS and PFS from the time of RIC allo-SCT for the entire population were 24.7 and 9.6 months, respectively. Cumulative non-relapse mortality (NRM) at 1 year was 21.5%. In multivariate analysis, CMV seronegativity of both patient and donor was associated with significantly better PFS, OS and NRM. Patient-donor gender mismatch was associated with better PFS, fewer than two prior auto-SCT was associated with better OS, and shorter time from the first auto-SCT to the RIC allo-SCT was associated with lower NRM. The results of this study identify patient and donor CMV seronegativity as the key prognostic factor for outcome after RIC allo-SCT for MM relapsing or progressing after prior auto-SCT. | ||
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