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Dynamic regulation of P-glycoprotein in human brain capillaries

Considering its role as a major blood-brain barrier gatekeeper, the dynamic regulation of the efflux transporter P-glycoprotein is of considerable functional relevance. In particular, disease-associated alterations in transport function might affect central nervous system drug efficacy. Thus, target...

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Main Authors: Avemary, Janine Verena (Author) , Salvamoser, Josephine D. (Author) , Peraud, Aurelia (Author) , Rémi, Jan (Author) , Noachtar, Soheyl (Author) , Fricker, Gert (Author) , Potschka, Heidrun (Author)
Format: Article (Journal)
Language:English
Published: July 18, 2013
In: Molecular pharmaceutics
Year: 2013, Volume: 10, Issue: 9, Pages: 3333-3341$9
ISSN:1543-8392
DOI:10.1021/mp4001102
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/mp4001102
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Author Notes:Janine Avemary, Josephine D. Salvamoser, Aurelia Peraud, Jan Rémi, Soheyl Noachtar, Gert Fricker, and Heidrun Potschka

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