mRNA 3′end processing: a tale of the tail reaches the clinic
Abstract Recent advances reveal mRNA 3?end processing as a highly regulated process that fine-tunes posttranscriptional gene expression. This process can affect the site and/or the efficiency of 3?end processing, controlling the quality and the quantity of substrate mRNAs. The regulation of 3?end pr...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2014
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| In: |
EMBO molecular medicine
Year: 2014, Jahrgang: 6, Heft: 1, Pages: 16-26 |
| ISSN: | 1757-4684 |
| DOI: | 10.1002/emmm.201303300 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/emmm.201303300 Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/full/10.1002/emmm.201303300 
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| Verfasserangaben: | Ina Hollerer, Kerstin Grund, Matthias W. Hentze & Andreas E Kulozik |
| Zusammenfassung: | Abstract Recent advances reveal mRNA 3?end processing as a highly regulated process that fine-tunes posttranscriptional gene expression. This process can affect the site and/or the efficiency of 3?end processing, controlling the quality and the quantity of substrate mRNAs. The regulation of 3?end processing plays a central role in fundamental physiology such as blood coagulation and innate immunity. In addition, errors in mRNA 3?end processing have been associated with a broad spectrum of human diseases, including cancer. We summarize and discuss the paradigmatic shift in the understanding of 3?end processing as a mechanism of posttranscriptional gene regulation that has reached clinical medicine. |
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| Beschreibung: | Published online 9 October 2013 Gesehen am 27.10.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1757-4684 |
| DOI: | 10.1002/emmm.201303300 |