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mRNA 3′end processing: a tale of the tail reaches the clinic

Abstract Recent advances reveal mRNA 3?end processing as a highly regulated process that fine-tunes posttranscriptional gene expression. This process can affect the site and/or the efficiency of 3?end processing, controlling the quality and the quantity of substrate mRNAs. The regulation of 3?end pr...

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Main Authors: Hollerer, Ina (Author) , Grund, Kerstin (Author) , Hentze, Matthias W. (Author) , Kulozik, Andreas (Author)
Format: Article (Journal)
Language:English
Published: 2014
In: EMBO molecular medicine
Year: 2014, Volume: 6, Issue: 1, Pages: 16-26
ISSN:1757-4684
DOI:10.1002/emmm.201303300
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/emmm.201303300
Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/full/10.1002/emmm.201303300
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Author Notes:Ina Hollerer, Kerstin Grund, Matthias W. Hentze & Andreas E Kulozik

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520 |a Abstract Recent advances reveal mRNA 3?end processing as a highly regulated process that fine-tunes posttranscriptional gene expression. This process can affect the site and/or the efficiency of 3?end processing, controlling the quality and the quantity of substrate mRNAs. The regulation of 3?end processing plays a central role in fundamental physiology such as blood coagulation and innate immunity. In addition, errors in mRNA 3?end processing have been associated with a broad spectrum of human diseases, including cancer. We summarize and discuss the paradigmatic shift in the understanding of 3?end processing as a mechanism of posttranscriptional gene regulation that has reached clinical medicine. 
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