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Association between C reactive protein and microvascular and macrovascular dysfunction in sub-Saharan Africans with and without diabetes: the RODAM study

Introduction Although inflammation assessed by elevated C reactive protein (CRP) concentration is known to be associated with risk of cardiovascular disease, its association with microvascular and macrovascular dysfunction in diabetes and non-diabetes remains unclear. We examined the association bet...

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Hauptverfasser: Hayfron-Benjamin, Charles F. (VerfasserIn) , Zee, Anke H. Maitland-van der (VerfasserIn) , Born, Bert-Jan van den (VerfasserIn) , Amoah, Albert G. B. (VerfasserIn) , Meeks, Karlijn A. C. (VerfasserIn) , Klipstein-Grobusch, Kerstin (VerfasserIn) , Schulze, Matthias B. (VerfasserIn) , Spranger, Joachim (VerfasserIn) , Danquah, Ina (VerfasserIn) , Smeeth, Liam (VerfasserIn) , Beune, Erik J. A. J. (VerfasserIn) , Mockenhaupt, Frank (VerfasserIn) , Agyemang, Charles O. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: July 14, 2020
In: BMJ Open Diabetes Research & Care
Year: 2020, Jahrgang: 8
ISSN:2052-4897
DOI:10.1136/bmjdrc-2020-001235
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/bmjdrc-2020-001235
Verlag, lizenzpflichtig, Volltext: https://drc.bmj.com/content/8/1/e001235
Volltext
Verfasserangaben:Charles Frederick Hayfron-Benjamin, Anke H. Maitland-van der Zee, Bert-Jan van den Born, Albert G.B. Amoah, Karlijn A.C. Meeks, Kerstin Klipstein-Grobusch, Matthias B. Schulze, Joachim Spranger, Ina Danquah, Liam Smeeth, Erik J.A.J. Beune, Frank Mockenhaupt, Charles O. Agyemang
Beschreibung
Zusammenfassung:Introduction Although inflammation assessed by elevated C reactive protein (CRP) concentration is known to be associated with risk of cardiovascular disease, its association with microvascular and macrovascular dysfunction in diabetes and non-diabetes remains unclear. We examined the association between CRP and diabetes and associated microvascular and macrovascular dysfunction in sub-Saharan Africans with and without diabetes. - Research design and methods Cross-sectional analyses of baseline data from the multicenter RODAM study (Research on Obesity and Diabetes among African Migrants) including 5248 Ghanaians (583 with diabetes, 4665 without diabetes) aged 25-70 years were done. Logistic regression analyses were used to examine the associations between CRP Z-scores and diabetes and microvascular (nephropathy) and macrovascular (peripheral artery disease (PAD)) dysfunction, with adjustments for age, sex, site of residence, smoking, body mass index, systolic blood pressure, and low-density lipoprotein cholesterol. - Results In the fully adjusted models, higher CRP concentration was significantly associated with diabetes (adjusted OR 1.13; 95% CI 1.05 to 1.21, p=0.002). In participants with diabetes, higher CRP concentration was associated with PAD (1.19; 1.03 to 1.41, p=0.046) but not nephropathy (1.13; 0.97 to 1.31, p=0.120). Among participants without diabetes, higher CRP concentration was associated with higher odds of PAD (1.10; 1.01 to 1.21, p=0.029) and nephropathy (1.12; 1.04 to 1.22, p=0.004). - Conclusions In this study, higher CRP concentration was associated with higher odds of diabetes in sub-Saharan Africans. Also, higher CRP concentration was associated with higher odds of nephropathy and PAD in non-diabetes and higher odds of PAD in diabetes. CRP may be an important marker for assessment of risk of diabetes and risk for PAD and nephropathy in sub-Saharan Africans with and without diabetes.
Beschreibung:Gesehen am 30.10.2020
Beschreibung:Online Resource
ISSN:2052-4897
DOI:10.1136/bmjdrc-2020-001235

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