Association between C reactive protein and microvascular and macrovascular dysfunction in sub-Saharan Africans with and without diabetes: the RODAM study
Introduction Although inflammation assessed by elevated C reactive protein (CRP) concentration is known to be associated with risk of cardiovascular disease, its association with microvascular and macrovascular dysfunction in diabetes and non-diabetes remains unclear. We examined the association bet...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 14, 2020
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| In: |
BMJ Open Diabetes Research & Care
Year: 2020, Jahrgang: 8 |
| ISSN: | 2052-4897 |
| DOI: | 10.1136/bmjdrc-2020-001235 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/bmjdrc-2020-001235 Verlag, lizenzpflichtig, Volltext: https://drc.bmj.com/content/8/1/e001235 
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| Verfasserangaben: | Charles Frederick Hayfron-Benjamin, Anke H. Maitland-van der Zee, Bert-Jan van den Born, Albert G.B. Amoah, Karlijn A.C. Meeks, Kerstin Klipstein-Grobusch, Matthias B. Schulze, Joachim Spranger, Ina Danquah, Liam Smeeth, Erik J.A.J. Beune, Frank Mockenhaupt, Charles O. Agyemang |
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| 245 | 1 | 0 | |a Association between C reactive protein and microvascular and macrovascular dysfunction in sub-Saharan Africans with and without diabetes |b the RODAM study |c Charles Frederick Hayfron-Benjamin, Anke H. Maitland-van der Zee, Bert-Jan van den Born, Albert G.B. Amoah, Karlijn A.C. Meeks, Kerstin Klipstein-Grobusch, Matthias B. Schulze, Joachim Spranger, Ina Danquah, Liam Smeeth, Erik J.A.J. Beune, Frank Mockenhaupt, Charles O. Agyemang |
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| 520 | |a Introduction Although inflammation assessed by elevated C reactive protein (CRP) concentration is known to be associated with risk of cardiovascular disease, its association with microvascular and macrovascular dysfunction in diabetes and non-diabetes remains unclear. We examined the association between CRP and diabetes and associated microvascular and macrovascular dysfunction in sub-Saharan Africans with and without diabetes. - Research design and methods Cross-sectional analyses of baseline data from the multicenter RODAM study (Research on Obesity and Diabetes among African Migrants) including 5248 Ghanaians (583 with diabetes, 4665 without diabetes) aged 25-70 years were done. Logistic regression analyses were used to examine the associations between CRP Z-scores and diabetes and microvascular (nephropathy) and macrovascular (peripheral artery disease (PAD)) dysfunction, with adjustments for age, sex, site of residence, smoking, body mass index, systolic blood pressure, and low-density lipoprotein cholesterol. - Results In the fully adjusted models, higher CRP concentration was significantly associated with diabetes (adjusted OR 1.13; 95% CI 1.05 to 1.21, p=0.002). In participants with diabetes, higher CRP concentration was associated with PAD (1.19; 1.03 to 1.41, p=0.046) but not nephropathy (1.13; 0.97 to 1.31, p=0.120). Among participants without diabetes, higher CRP concentration was associated with higher odds of PAD (1.10; 1.01 to 1.21, p=0.029) and nephropathy (1.12; 1.04 to 1.22, p=0.004). - Conclusions In this study, higher CRP concentration was associated with higher odds of diabetes in sub-Saharan Africans. Also, higher CRP concentration was associated with higher odds of nephropathy and PAD in non-diabetes and higher odds of PAD in diabetes. CRP may be an important marker for assessment of risk of diabetes and risk for PAD and nephropathy in sub-Saharan Africans with and without diabetes. | ||
| 650 | 4 | |a adult diabetes | |
| 650 | 4 | |a C-reactive protein | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a microvascular and macrovascular complications | |
| 700 | 1 | |a Zee, Anke H. Maitland-van der |e VerfasserIn |4 aut | |
| 700 | 1 | |a Born, Bert-Jan van den |e VerfasserIn |4 aut | |
| 700 | 1 | |a Amoah, Albert G. B. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Meeks, Karlijn A. C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Klipstein-Grobusch, Kerstin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schulze, Matthias B. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Spranger, Joachim |e VerfasserIn |4 aut | |
| 700 | 1 | |a Danquah, Ina |d 1982- |e VerfasserIn |0 (DE-588)115451353X |0 (DE-627)101580618X |0 (DE-576)501055223 |4 aut | |
| 700 | 1 | |a Smeeth, Liam |e VerfasserIn |4 aut | |
| 700 | 1 | |a Beune, Erik J. A. J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mockenhaupt, Frank |e VerfasserIn |4 aut | |
| 700 | 1 | |a Agyemang, Charles O. |e VerfasserIn |4 aut | |
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