Specific creatine rise in learned helplessness induced by electroconvulsive shock treatment
Metabolic changes in the hippocampus formation can be investigated with in vivo magnetic resonance spectroscopy (MRS). Learned helplessness (LH) is a well validated animal model of depression which we established in Sprague-Dawley rats defining some as “learned helpless” (LH) or not “learned helples...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
December 2nd, 2003
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| In: |
Neuroreport
Year: 2003, Volume: 14, Issue: 17, Pages: 2199-2201 |
| ISSN: | 1473-558X |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/neuroreport/Abstract/2003/12020/Specific_creatine_rise_in_learned_helplessness.13.aspx
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| Author Notes: | Alexander Sartorius, Barbara Vollmayr, Claudia Neumann-Haefelin, Gabriele Ende, Mathias Hoehn, Fritz A. Henn |
MARC
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| 520 | |a Metabolic changes in the hippocampus formation can be investigated with in vivo magnetic resonance spectroscopy (MRS). Learned helplessness (LH) is a well validated animal model of depression which we established in Sprague-Dawley rats defining some as “learned helpless” (LH) or not “learned helpless” (NLH). Helpless and non-helpless rats received a course of daily administered electroconvulsive shocks (ECS) for 6 days. MRS measurements were performed on a 4.7 T animal scanner with an average voxel size within the rat hippocampus of 10 μl. In LH rats hippocampal creatine/NAA rose significantly (14%) whereas creatine/NAA of NLH rats showed no increase at all. A possible connection between hippocampal creatine levels and major depressive disorders as a reflection of changes in energy metabolism is discussed. | ||
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