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Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts

<h2>Abstract</h2><h3>Background</h3><p>Decreased sensitivity to and increased tolerance for the effects of alcohol is a phenotype, which was shown to be associated with an increased risk for alcoholism in humans and was observed in protein tyrosine kinase (PTK) fyn knoc...

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Main Authors: Schumann, Gunter (Author) , Rujescu, Dan (Author) , Kissling, Christian (Author) , Soyka, Michael (Author) , Dahmen, Norbert (Author) , Preuss, Ullrich W. (Author) , Wiemann, Stefan (Author) , Depner, Martin (Author) , Wellek, Stefan (Author) , Lascorz Puértolas, Jesús (Author) , Bondy, Brigitta (Author) , Giegling, Ina (Author) , Anghelescu, Ion-George (Author) , Cowen, Michael S. (Author) , Poustka, Annemarie (Author) , Spanagel, Rainer (Author) , Mann, Karl (Author) , Henn, Fritz A. (Author) , Szegedi, Armin (Author)
Format: Article (Journal)
Language:English
Published: December 15, 2003
In: Biological psychiatry
Year: 2003, Volume: 54, Issue: 12, Pages: 1422-1426
ISSN:1873-2402
DOI:10.1016/S0006-3223(03)00635-8
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0006-3223(03)00635-8
Verlag, lizenzpflichtig, Volltext: https://www.biologicalpsychiatryjournal.com/article/S0006-3223(03)00635-8/abstract
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Author Notes:Gunter Schumann, Dan Rujescu, Christian Kissling, Michael Soyka, Norbert Dahmen, Ullrich W. Preuss, Stefan Wieman, Martin Depner, Stefan Wellek, Jesús Lascorz, Brigitta Bondy, Ina Giegling, Ion Anghelescu, Michael S. Cowen, Annemarie Poustka, Rainer Spanagel, Karl Mann, Fritz A. Henn, Armin Szegedi
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Summary:<h2>Abstract</h2><h3>Background</h3><p>Decreased sensitivity to and increased tolerance for the effects of alcohol is a phenotype, which was shown to be associated with an increased risk for alcoholism in humans and was observed in protein tyrosine kinase (PTK) fyn knockout mice.</p><h3>Methods</h3><p>We performed an association study of genetic variations of PTK fyn in 430 alcohol-dependent patients and 365 unrelated control subjects from two independent samples.</p><h3>Results</h3><p>In a combined analysis, we found an association of alcohol dependence with the single nucleotide polymorphism (SNP) T137346C in the 5′ untranslated region (UTR) of the gene. A relevant association could be excluded for the remaining two informative SNPs. Selection by phenotype showed that a high number of withdrawal symptoms, high amount of alcohol intake, and high maximum number of drinks compared with unrelated control subjects was associated with the SNP in the 5′-UTR region but not with the remaining SNPs.</p><h3>Conclusions</h3><p>Our results indicate a possible association of alcohol dependence with a genotype of the SNP T137346C of the PTK fyn, with C being the risk allele.</p>
Item Description:Gesehen am 03.11.2020
Physical Description:Online Resource
ISSN:1873-2402
DOI:10.1016/S0006-3223(03)00635-8

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