Phosphorylation of T107 by CamKII[delta] regulates the detoxification efficiency and proteomic integrity of glyoxalase 1
The glyoxalase system is a highly conserved and ubiquitously expressed enzyme system, which is responsible for the detoxification of methylglyoxal (MG), a spontaneous by-product of energy metabolism. This study is able to show that a phosphorylation of threonine-107 (T107) in the (rate-limiting) Gly...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 22, 2020
|
| In: |
Cell reports
Year: 2020, Jahrgang: 32, Heft: 12 |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2020.108160 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.celrep.2020.108160 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S2211124720311499 
|
| Verfasserangaben: | Jakob Morgenstern, Sylvia Katz, Jutta Krebs-Haupenthal, Jessy Chen, Alireza Saadatmand, Fabiola Garcia Cortizo, Alexandra Moraru, Johanna Zemva, Marta Campos Campos, Aurelio Teleman, Johannes Backs, Peter Nawroth, and Thomas Fleming |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1737628457 | ||
| 003 | DE-627 | ||
| 005 | 20220819011034.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201103s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.celrep.2020.108160 |2 doi | |
| 035 | |a (DE-627)1737628457 | ||
| 035 | |a (DE-599)KXP1737628457 | ||
| 035 | |a (OCoLC)1341375426 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Morgenstern, Jakob |d 1985- |e VerfasserIn |0 (DE-588)1129805832 |0 (DE-627)884397599 |0 (DE-576)486560864 |4 aut | |
| 245 | 1 | 0 | |a Phosphorylation of T107 by CamKII[delta] regulates the detoxification efficiency and proteomic integrity of glyoxalase 1 |c Jakob Morgenstern, Sylvia Katz, Jutta Krebs-Haupenthal, Jessy Chen, Alireza Saadatmand, Fabiola Garcia Cortizo, Alexandra Moraru, Johanna Zemva, Marta Campos Campos, Aurelio Teleman, Johannes Backs, Peter Nawroth, and Thomas Fleming |
| 246 | 3 | 0 | |a δ one hundred and seven |
| 246 | 3 | 3 | |a Phosphorylation of T107 by CamKII delta regulates the detoxification efficiency and proteomic integrity of glyoxalase 1 |
| 264 | 1 | |c September 22, 2020 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Im Titel wird delta als griechischer Buchstabe dargestellt | ||
| 500 | |a Gesehen am 03.11.2020 | ||
| 520 | |a The glyoxalase system is a highly conserved and ubiquitously expressed enzyme system, which is responsible for the detoxification of methylglyoxal (MG), a spontaneous by-product of energy metabolism. This study is able to show that a phosphorylation of threonine-107 (T107) in the (rate-limiting) Glyoxalase 1 (Glo1) protein, mediated by Ca2+/calmodulin-dependent kinase II delta (CamKIIδ), is associated with elevated catalytic efficiency of Glo1 (lower KM; higher Vmax). Additionally, we observe proteasomal degradation of non-phosphorylated Glo1 via ubiquitination does occur more rapidly as compared with native Glo1. The absence of CamKIIδ is associated with poor detoxification capacity and decreased protein content of Glo1 in a murine CamKIIδ knockout model. Therefore, phosphorylation of T107 in the Glo1 protein by CamKIIδ is a quick and precise mechanism regulating Glo1 activity, which is experimentally linked to an altered Glo1 status in cancer, diabetes, and during aging. | ||
| 650 | 4 | |a aging | |
| 650 | 4 | |a Ca/calmodulin-dependent kinase | |
| 650 | 4 | |a cancer | |
| 650 | 4 | |a cellular biochemistry | |
| 650 | 4 | |a diabetes | |
| 650 | 4 | |a glyoxalase system | |
| 650 | 4 | |a methylglyoxal | |
| 650 | 4 | |a Michaelis-Menten kinetics | |
| 650 | 4 | |a phosphorylation | |
| 650 | 4 | |a post-translational modifications | |
| 700 | 1 | |a Katz, Sylvia |e VerfasserIn |0 (DE-588)1169704190 |0 (DE-627)1035308266 |0 (DE-576)512214980 |4 aut | |
| 700 | 1 | |a Krebs-Haupenthal, Jutta |e VerfasserIn |0 (DE-588)1059323575 |0 (DE-627)798300000 |0 (DE-576)415329590 |4 aut | |
| 700 | 1 | |a Chen, Jessy |d 1993- |e VerfasserIn |0 (DE-588)1220744255 |0 (DE-627)1737687283 |4 aut | |
| 700 | 1 | |a Saadatmand, Ali R. |e VerfasserIn |0 (DE-588)1160092400 |0 (DE-627)1023233703 |0 (DE-576)505503808 |4 aut | |
| 700 | 1 | |a Garcia Cortizo, Fabiola |d 1989- |e VerfasserIn |0 (DE-588)1220745251 |0 (DE-627)1737688719 |4 aut | |
| 700 | 1 | |a Zemva, Johanna |d 1986- |e VerfasserIn |0 (DE-588)1067679324 |0 (DE-627)819077364 |0 (DE-576)426841433 |4 aut | |
| 700 | 1 | |a Campos Campos, Marta |d 1995- |e VerfasserIn |0 (DE-588)1220745960 |0 (DE-627)1737689812 |4 aut | |
| 700 | 1 | |a Teleman, Aurelio A. |d 1976- |e VerfasserIn |0 (DE-588)1155118294 |0 (DE-627)1016370121 |0 (DE-576)501431861 |4 aut | |
| 700 | 1 | |a Backs, Johannes |d 1971- |e VerfasserIn |0 (DE-588)123819040 |0 (DE-627)706437462 |0 (DE-576)293892946 |4 aut | |
| 700 | 1 | |a Nawroth, Peter Paul |d 1954- |e VerfasserIn |0 (DE-588)1020504897 |0 (DE-627)69123941X |0 (DE-576)360517692 |4 aut | |
| 700 | 1 | |a Fleming, Thomas |d 1982- |e VerfasserIn |0 (DE-588)1034445294 |0 (DE-627)745607365 |0 (DE-576)382066804 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell reports |d Maryland Heights, MO : Cell Press, 2012 |g 32(2020,12) Artikel-Nummer 108160, 14 Seiten |h Online-Ressource |w (DE-627)684964562 |w (DE-600)2649101-1 |w (DE-576)358411572 |x 2211-1247 |7 nnas |a Phosphorylation of T107 by CamKII[delta] regulates the detoxification efficiency and proteomic integrity of glyoxalase 1 |
| 773 | 1 | 8 | |g volume:32 |g year:2020 |g number:12 |g extent:14 |a Phosphorylation of T107 by CamKII[delta] regulates the detoxification efficiency and proteomic integrity of glyoxalase 1 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.celrep.2020.108160 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S2211124720311499 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201103 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1034445294 |a Fleming, Thomas |m 1034445294:Fleming, Thomas |d 910000 |d 910100 |e 910000PF1034445294 |e 910100PF1034445294 |k 0/910000/ |k 1/910000/910100/ |p 13 |y j | ||
| 998 | |g 1020504897 |a Nawroth, Peter Paul |m 1020504897:Nawroth, Peter Paul |d 910000 |d 910100 |e 910000PN1020504897 |e 910100PN1020504897 |k 0/910000/ |k 1/910000/910100/ |p 12 | ||
| 998 | |g 123819040 |a Backs, Johannes |m 123819040:Backs, Johannes |d 910000 |d 910100 |e 910000PB123819040 |e 910100PB123819040 |k 0/910000/ |k 1/910000/910100/ |p 11 | ||
| 998 | |g 1155118294 |a Teleman, Aurelio A. |m 1155118294:Teleman, Aurelio A. |d 140000 |e 140000PT1155118294 |k 0/140000/ |p 10 | ||
| 998 | |g 1220745960 |a Campos Campos, Marta |m 1220745960:Campos Campos, Marta |d 910000 |d 910100 |e 910000PC1220745960 |e 910100PC1220745960 |k 0/910000/ |k 1/910000/910100/ |p 9 | ||
| 998 | |g 1067679324 |a Zemva, Johanna |m 1067679324:Zemva, Johanna |d 910000 |d 910100 |e 910000PZ1067679324 |e 910100PZ1067679324 |k 0/910000/ |k 1/910000/910100/ |p 8 | ||
| 998 | |g 1220745251 |a Garcia Cortizo, Fabiola |m 1220745251:Garcia Cortizo, Fabiola |d 140000 |e 140000PG1220745251 |k 0/140000/ |p 6 | ||
| 998 | |g 1160092400 |a Saadatmand, Ali R. |m 1160092400:Saadatmand, Ali R. |d 910000 |d 910100 |e 910000PS1160092400 |e 910100PS1160092400 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 1220744255 |a Chen, Jessy |m 1220744255:Chen, Jessy |d 50000 |e 50000PC1220744255 |k 0/50000/ |p 4 | ||
| 998 | |g 1059323575 |a Krebs-Haupenthal, Jutta |m 1059323575:Krebs-Haupenthal, Jutta |d 910000 |d 910100 |e 910000PK1059323575 |e 910100PK1059323575 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1169704190 |a Katz, Sylvia |m 1169704190:Katz, Sylvia |d 910000 |e 910000PK1169704190 |k 0/910000/ |p 2 | ||
| 998 | |g 1129805832 |a Morgenstern, Jakob |m 1129805832:Morgenstern, Jakob |d 910000 |d 910100 |e 910000PM1129805832 |e 910100PM1129805832 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1737628457 |e 3791546171 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Morgenstern","given":"Jakob","display":"Morgenstern, Jakob","role":"aut"},{"display":"Katz, Sylvia","given":"Sylvia","family":"Katz","role":"aut"},{"given":"Jutta","display":"Krebs-Haupenthal, Jutta","family":"Krebs-Haupenthal","role":"aut"},{"role":"aut","display":"Chen, Jessy","given":"Jessy","family":"Chen"},{"role":"aut","display":"Saadatmand, Ali R.","given":"Ali R.","family":"Saadatmand"},{"family":"Garcia Cortizo","given":"Fabiola","display":"Garcia Cortizo, Fabiola","role":"aut"},{"role":"aut","display":"Zemva, Johanna","given":"Johanna","family":"Zemva"},{"display":"Campos Campos, Marta","given":"Marta","family":"Campos Campos","role":"aut"},{"display":"Teleman, Aurelio A.","given":"Aurelio A.","family":"Teleman","role":"aut"},{"display":"Backs, Johannes","given":"Johannes","family":"Backs","role":"aut"},{"role":"aut","family":"Nawroth","display":"Nawroth, Peter Paul","given":"Peter Paul"},{"family":"Fleming","given":"Thomas","display":"Fleming, Thomas","role":"aut"}],"name":{"displayForm":["Jakob Morgenstern, Sylvia Katz, Jutta Krebs-Haupenthal, Jessy Chen, Alireza Saadatmand, Fabiola Garcia Cortizo, Alexandra Moraru, Johanna Zemva, Marta Campos Campos, Aurelio Teleman, Johannes Backs, Peter Nawroth, and Thomas Fleming"]},"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"September 22, 2020"}],"recId":"1737628457","title":[{"title":"Phosphorylation of T107 by CamKII[delta] regulates the detoxification efficiency and proteomic integrity of glyoxalase 1","title_sort":"Phosphorylation of T107 by CamKII[delta] regulates the detoxification efficiency and proteomic integrity of glyoxalase 1"}],"language":["eng"],"titleAlt":[{"title":"Phosphorylation of T107 by CamKII delta regulates the detoxification efficiency and proteomic integrity of glyoxalase 1"}],"physDesc":[{"extent":"14 S."}],"id":{"eki":["1737628457"],"doi":["10.1016/j.celrep.2020.108160"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Im Titel wird delta als griechischer Buchstabe dargestellt","Gesehen am 03.11.2020"],"relHost":[{"origin":[{"publisher":"Cell Press ; Elsevier","dateIssuedDisp":"2012-","dateIssuedKey":"2012","publisherPlace":"Maryland Heights, MO ; [New York, NY]"}],"disp":"Phosphorylation of T107 by CamKII[delta] regulates the detoxification efficiency and proteomic integrity of glyoxalase 1Cell reports","recId":"684964562","title":[{"title":"Cell reports","title_sort":"Cell reports"}],"language":["eng"],"pubHistory":["1.2012 -"],"id":{"issn":["2211-1247"],"zdb":["2649101-1"],"eki":["684964562"]},"part":{"extent":"14","year":"2020","issue":"12","text":"32(2020,12) Artikel-Nummer 108160, 14 Seiten","volume":"32"},"type":{"media":"Online-Ressource","bibl":"periodical"},"physDesc":[{"extent":"Online-Ressource"}]}]} | ||
| SRT | |a MORGENSTERPHOSPHORYL2220 | ||