Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease
In order to identify gene variants related to the serotonergic neurotransmitter system that possibly represent a hereditary risk factor for sporadic Alzheimer's disease (AD), patients suffering from AD and non-demented psychiatric inpatients without symptoms of dementia were genotyped for polym...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 2001
|
| In: |
Journal of neural transmission
Year: 2001, Jahrgang: 108, Heft: 10, Pages: 1175-1180 |
| ISSN: | 1435-1463 |
| DOI: | 10.1007/s007020170007 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s007020170007
|
| Verfasserangaben: | J. Thome, W. Retz, M. Baader, B. Pesold, M. Hu, M. Cowen, N. Durany, G. Adler, F.A. Henn, and M. Rösler |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1737747197 | ||
| 003 | DE-627 | ||
| 005 | 20230426153254.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201104s2001 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s007020170007 |2 doi | |
| 035 | |a (DE-627)1737747197 | ||
| 035 | |a (DE-599)KXP1737747197 | ||
| 035 | |a (OCoLC)1341375740 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Thome, Johannes |e VerfasserIn |0 (DE-588)1079452567 |0 (DE-627)841132399 |0 (DE-576)172532957 |4 aut | |
| 245 | 1 | 0 | |a Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease |c J. Thome, W. Retz, M. Baader, B. Pesold, M. Hu, M. Cowen, N. Durany, G. Adler, F.A. Henn, and M. Rösler |
| 264 | 1 | |c October 2001 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.11.2020 | ||
| 520 | |a In order to identify gene variants related to the serotonergic neurotransmitter system that possibly represent a hereditary risk factor for sporadic Alzheimer's disease (AD), patients suffering from AD and non-demented psychiatric inpatients without symptoms of dementia were genotyped for polymorphisms of HTR6 (267C/T) and HTR2A (−1438G/A). Although there was a tendency toward an increased number of the genotype TT of the 5-HT6 receptor polymorphism in AD patients when compared to controls (2.8% vs. 1.3%), neither this nor the 5-HT2A promoter polymorphism showed significant differences in their genotypic or allelic distribution among patients and controls. These polymorphisms probably do not represent major genetic risk factors of AD. However, further studies including other genetic variants of the serotonergic neurotransmitter system are needed in order to elucidate their role in AD. | ||
| 700 | 1 | |a Retz, Wolfgang |d 1964- |e VerfasserIn |0 (DE-588)120431130 |0 (DE-627)080670024 |0 (DE-576)292214502 |4 aut | |
| 700 | 1 | |a Baader, Miriam |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pesold, B. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hu, Mei |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cowen, M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Durany, N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Adler, G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Henn, Fritz A. |d 1941- |e VerfasserIn |0 (DE-588)17213384X |0 (DE-627)697047938 |0 (DE-576)133005917 |4 aut | |
| 700 | 1 | |a Rösler, Michael |d 1951- |e VerfasserIn |0 (DE-588)140421904 |0 (DE-627)618383948 |0 (DE-576)318039923 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neural transmission |d Wien [u.a.] : Springer, 1950 |g 108(2001), 10, Seite 1175-1180 |h Online-Ressource |w (DE-627)300185901 |w (DE-600)1481655-6 |w (DE-576)09450542X |x 1435-1463 |7 nnas |a Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease |
| 773 | 1 | 8 | |g volume:108 |g year:2001 |g number:10 |g pages:1175-1180 |g extent:6 |a Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s007020170007 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201104 | ||
| 993 | |a Article | ||
| 994 | |a 2001 | ||
| 998 | |g 17213384X |a Henn, Fritz A. |m 17213384X:Henn, Fritz A. |d 60000 |e 60000PH17213384X |k 0/60000/ |p 9 | ||
| 999 | |a KXP-PPN1737747197 |e 3792117568 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"id":{"doi":["10.1007/s007020170007"],"eki":["1737747197"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"October 2001","dateIssuedKey":"2001"}],"person":[{"role":"aut","given":"Johannes","display":"Thome, Johannes","family":"Thome"},{"display":"Retz, Wolfgang","family":"Retz","given":"Wolfgang","role":"aut"},{"role":"aut","display":"Baader, Miriam","family":"Baader","given":"Miriam"},{"given":"B.","family":"Pesold","display":"Pesold, B.","role":"aut"},{"role":"aut","family":"Hu","display":"Hu, Mei","given":"Mei"},{"role":"aut","display":"Cowen, M.","family":"Cowen","given":"M."},{"role":"aut","given":"N.","family":"Durany","display":"Durany, N."},{"family":"Adler","display":"Adler, G.","given":"G.","role":"aut"},{"display":"Henn, Fritz A.","family":"Henn","given":"Fritz A.","role":"aut"},{"role":"aut","given":"Michael","display":"Rösler, Michael","family":"Rösler"}],"physDesc":[{"extent":"6 S."}],"title":[{"title":"Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease","title_sort":"Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease"}],"relHost":[{"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"eki":["300185901"],"zdb":["1481655-6"],"issn":["1435-1463"]},"corporate":[{"role":"isb","display":"European Society for Clinical Neuropharmacology"}],"origin":[{"publisher":"Springer","dateIssuedKey":"1950","dateIssuedDisp":"1950-","publisherPlace":"Wien [u.a.]"}],"titleAlt":[{"title":"Acta neurovegetativa"},{"title":"Journal of neuro-visceral relations"},{"title":"Journal of neural transmission / General section"}],"title":[{"title_sort":"Journal of neural transmission","title":"Journal of neural transmission"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"text":"108(2001), 10, Seite 1175-1180","pages":"1175-1180","volume":"108","issue":"10","extent":"6","year":"2001"},"disp":"Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's diseaseJournal of neural transmission","pubHistory":["1.1950 -"],"recId":"300185901","note":["Gesehen am 18.10.05"]}],"name":{"displayForm":["J. Thome, W. Retz, M. Baader, B. Pesold, M. Hu, M. Cowen, N. Durany, G. Adler, F.A. Henn, and M. Rösler"]},"note":["Gesehen am 04.11.2020"],"recId":"1737747197"} | ||
| SRT | |a THOMEJOHANASSOCIATIO2001 | ||