Improved oral bioavailability of human growth hormone by a combination of liposomes containing bio-enhancers and tetraether lipids and omeprazole
ABSTRACT: Liposomes for the oral delivery of human growth hormone (hGH) containing bio-enhancers and tetraether lipids were prepared by dual asymmetric centrifugation. Cetylpyridinium chloride (CpCl), d-α-tocopheryl polyethylene glycol 400 succinate, phenylpiperazine, sodium caprate or octadecanethi...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 October 2014
|
| In: |
Journal of pharmaceutical sciences
Year: 2014, Jahrgang: 103, Heft: 12, Pages: 3985-3993 |
| ISSN: | 1520-6017 |
| DOI: | 10.1002/jps.24215 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/jps.24215 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0022354915303026 
|
| Verfasserangaben: | Johannes Parmentier, Götz Hofhaus, Silke Thomas, Laura Clusa Cuesta, Felix Gropp, Rasmus Schröder, Klaus Hartmann, Gert Fricker |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1737749394 | ||
| 003 | DE-627 | ||
| 005 | 20230426153254.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201104s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/jps.24215 |2 doi | |
| 035 | |a (DE-627)1737749394 | ||
| 035 | |a (DE-599)KXP1737749394 | ||
| 035 | |a (OCoLC)1341375502 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Parmentier, Johannes |e VerfasserIn |0 (DE-588)1019157801 |0 (DE-627)684202662 |0 (DE-576)357136225 |4 aut | |
| 245 | 1 | 0 | |a Improved oral bioavailability of human growth hormone by a combination of liposomes containing bio-enhancers and tetraether lipids and omeprazole |c Johannes Parmentier, Götz Hofhaus, Silke Thomas, Laura Clusa Cuesta, Felix Gropp, Rasmus Schröder, Klaus Hartmann, Gert Fricker |
| 264 | 1 | |c 20 October 2014 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.11.2020 | ||
| 520 | |a ABSTRACT: Liposomes for the oral delivery of human growth hormone (hGH) containing bio-enhancers and tetraether lipids were prepared by dual asymmetric centrifugation. Cetylpyridinium chloride (CpCl), d-α-tocopheryl polyethylene glycol 400 succinate, phenylpiperazine, sodium caprate or octadecanethiol were used as permeation enhancers. In vitro data showed that oligolamellar vesicles with average size in the range of 200-250nm were formed. Performance of the formulations was investigated both ex vivo by confocal microscopy scans of sections of rat small intestine and in vivo by comparing the area under the plasma curve of hGH after oral or subcutaneous (s.c.) application. The microscopic data reveal an interaction between the liposomal formulation and the intestinal mucus layer. Particularly one formulation, which was designed to be mucus penetrative by addition of a high quantity of TPGS 400 and a ζ-potential close to 0mV, showed a very strong mucus association in the duodenum and jejunum. Vesicles with CpCl 33% (mol/mol) led to a relative hGH bioavailability of 3.4% compared with s.c. control, whereas free hGH administered orally showed a bioavailability of only 0.01%. | ||
| 650 | 4 | |a archae | |
| 650 | 4 | |a dual asymmetric centrifugation | |
| 650 | 4 | |a imaging methods | |
| 650 | 4 | |a lipogelosomes | |
| 650 | 4 | |a liposomes | |
| 650 | 4 | |a oral absorption | |
| 650 | 4 | |a permeation enhancers | |
| 650 | 4 | |a proteins | |
| 700 | 1 | |a Hofhaus, Götz |e VerfasserIn |0 (DE-588)1143571258 |0 (DE-627)1002793947 |0 (DE-576)49505979X |4 aut | |
| 700 | 1 | |a Schröder, Rasmus R. |e VerfasserIn |0 (DE-588)1070886483 |0 (DE-627)824718895 |0 (DE-576)165430702 |4 aut | |
| 700 | 1 | |a Fricker, Gert |d 1956- |e VerfasserIn |0 (DE-588)1042227675 |0 (DE-627)768469465 |0 (DE-576)393783464 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of pharmaceutical sciences |d Amsterdam : Elsevier, 1911 |g 103(2014), 12, Seite 3985-3993 |h Online-Ressource |w (DE-627)302718028 |w (DE-600)1491821-3 |w (DE-576)090855167 |x 1520-6017 |7 nnas |a Improved oral bioavailability of human growth hormone by a combination of liposomes containing bio-enhancers and tetraether lipids and omeprazole |
| 773 | 1 | 8 | |g volume:103 |g year:2014 |g number:12 |g pages:3985-3993 |g extent:9 |a Improved oral bioavailability of human growth hormone by a combination of liposomes containing bio-enhancers and tetraether lipids and omeprazole |
| 856 | 4 | 0 | |u https://doi.org/10.1002/jps.24215 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0022354915303026 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201104 | ||
| 993 | |a Article | ||
| 994 | |a 2014 | ||
| 998 | |g 1042227675 |a Fricker, Gert |m 1042227675:Fricker, Gert |d 160000 |d 160100 |e 160000PF1042227675 |e 160100PF1042227675 |k 0/160000/ |k 1/160000/160100/ |p 8 |y j | ||
| 998 | |g 1070886483 |a Schröder, Rasmus R. |m 1070886483:Schröder, Rasmus R. |d 910000 |d 911700 |e 910000PS1070886483 |e 911700PS1070886483 |k 0/910000/ |k 1/910000/911700/ |p 6 | ||
| 998 | |g 1143571258 |a Hofhaus, Götz |m 1143571258:Hofhaus, Götz |d 910000 |d 911700 |e 910000PH1143571258 |e 911700PH1143571258 |k 0/910000/ |k 1/910000/911700/ |p 2 | ||
| 999 | |a KXP-PPN1737749394 |e 3792123584 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"name":{"displayForm":["American Chemical Society"]},"note":["Gesehen am 07.02.13"],"disp":"Improved oral bioavailability of human growth hormone by a combination of liposomes containing bio-enhancers and tetraether lipids and omeprazoleJournal of pharmaceutical sciences","physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Journal of pharmaceutical sciences","title_sort":"Journal of pharmaceutical sciences"}],"language":["eng"],"origin":[{"publisherPlace":"Amsterdam ; Washington, DC [u.a.] ; New York, NY","dateIssuedKey":"1911","publisher":"Elsevier ; American Chemical Society and American Pharmaceutical Association ; Wiley","dateIssuedDisp":"1911-"}],"titleAlt":[{"title":"Journal of the American Pharmaceutical Association"}],"recId":"302718028","id":{"eki":["302718028"],"doi":["10.1002/(ISSN)1520-6017"],"zdb":["1491821-3"],"issn":["1520-6017"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"volume":"103","year":"2014","extent":"9","issue":"12","pages":"3985-3993","text":"103(2014), 12, Seite 3985-3993"},"pubHistory":["1.1911 -"]}],"title":[{"title":"Improved oral bioavailability of human growth hormone by a combination of liposomes containing bio-enhancers and tetraether lipids and omeprazole","title_sort":"Improved oral bioavailability of human growth hormone by a combination of liposomes containing bio-enhancers and tetraether lipids and omeprazole"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1002/jps.24215"],"eki":["1737749394"]},"physDesc":[{"extent":"9 S."}],"language":["eng"],"person":[{"family":"Parmentier","given":"Johannes","display":"Parmentier, Johannes","role":"aut"},{"family":"Hofhaus","given":"Götz","display":"Hofhaus, Götz","role":"aut"},{"display":"Schröder, Rasmus R.","role":"aut","family":"Schröder","given":"Rasmus R."},{"given":"Gert","family":"Fricker","role":"aut","display":"Fricker, Gert"}],"origin":[{"dateIssuedDisp":"20 October 2014","dateIssuedKey":"2014"}],"note":["Gesehen am 04.11.2020"],"recId":"1737749394","name":{"displayForm":["Johannes Parmentier, Götz Hofhaus, Silke Thomas, Laura Clusa Cuesta, Felix Gropp, Rasmus Schröder, Klaus Hartmann, Gert Fricker"]}} | ||
| SRT | |a PARMENTIERIMPROVEDOR2020 | ||