Effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits
Postmortem studies in schizophrenic patients revealed alterations in NMDA receptor binding and gene expression of specific subunits. Because most of the patients had been treated with antipsychotics over long periods, medication effects might have influenced those findings. We treated animals with h...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 2003
|
| In: |
Neurochemical research
Year: 2003, Jahrgang: 28, Heft: 2, Pages: 235-241 |
| ISSN: | 1573-6903 |
| DOI: | 10.1023/A:1022325116309 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1023/A:1022325116309
|
| Verfasserangaben: | Andrea Schmitt, Mathias Zink, Bettina Müller, Brigitte May, Anne Herb, Alexander Jatzko, Dieter F. Braus, and Fritz A. Henn |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 173798024X | ||
| 003 | DE-627 | ||
| 005 | 20230712095029.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201105s2003 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1023/A:1022325116309 |2 doi | |
| 035 | |a (DE-627)173798024X | ||
| 035 | |a (DE-599)KXP173798024X | ||
| 035 | |a (OCoLC)1341375442 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schmitt, Andrea |e VerfasserIn |0 (DE-588)1045120928 |0 (DE-627)773824014 |0 (DE-576)39876655X |4 aut | |
| 245 | 1 | 0 | |a Effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits |c Andrea Schmitt, Mathias Zink, Bettina Müller, Brigitte May, Anne Herb, Alexander Jatzko, Dieter F. Braus, and Fritz A. Henn |
| 264 | 1 | |c February 2003 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.11.2020 | ||
| 520 | |a Postmortem studies in schizophrenic patients revealed alterations in NMDA receptor binding and gene expression of specific subunits. Because most of the patients had been treated with antipsychotics over long periods, medication effects might have influenced those findings. We treated animals with haloperidol and clozapine in clinical doses to investigate the effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits. Rats were treated with either haloperidol (1,5 mg/kg/day) or clozapine (45 mg/kg/day) given in drinking water over a period of 6 months. Quantitative receptor autoradiography with [3H]-MK-801 was used to examine NMDA receptor binding. In situ hybridization was performed for additional gene expression studies of the NR1, NR2A, NR2B, NR2C, and NR2D subunits. [3H]-MK-801 binding was found to be increased after haloperidol treatment in the striatum and nucleus accumbens. Clozapine was shown to up-regulate NMDA receptor binding only in the nucleus accumbens. There were no alterations in gene expression of NMDA subunits in any of the three regions. However, the NR2A subunit was down-regulated in the hippocampus and prefrontal cortex by both drugs, whereas only clozapine induced a down-regulation of NR1 in the dorsolateral prefrontal cortex. NR2B, 2C, and 2D subunits did not differ between treatment groups and controls. Both altered NMDA receptor binding and subunit expression strengthen a hyperglutamatergic function after haloperidol treatment and may contribute to some of our postmortem findings in antipsychotically treated schizophrenic patients. Because the effects seen in different brain areas clearly vary between haloperidol and clozapine, they may also be responsible for some of the differences in efficacy and side effects. | ||
| 700 | 1 | |a Zink, Mathias |d 1968- |e VerfasserIn |0 (DE-588)121715221 |0 (DE-627)705627217 |0 (DE-576)292845715 |4 aut | |
| 700 | 1 | |a Müller, Bettina |e VerfasserIn |4 aut | |
| 700 | 1 | |a May, Brigitte |e VerfasserIn |0 (DE-588)132388758 |0 (DE-627)521953634 |0 (DE-576)299115186 |4 aut | |
| 700 | 1 | |a Herb, Anne |e VerfasserIn |0 (DE-588)1070544396 |0 (DE-627)824003985 |0 (DE-576)430208383 |4 aut | |
| 700 | 1 | |a Jatzko, Alexander |d 1971- |e VerfasserIn |0 (DE-588)120987589 |0 (DE-627)081012772 |0 (DE-576)180860542 |4 aut | |
| 700 | 1 | |a Braus, Dieter F. |e VerfasserIn |0 (DE-588)111308712 |0 (DE-627)483645125 |0 (DE-576)289698472 |4 aut | |
| 700 | 1 | |a Henn, Fritz A. |d 1941- |e VerfasserIn |0 (DE-588)17213384X |0 (DE-627)697047938 |0 (DE-576)133005917 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neurochemical research |d Dordrecht [u.a.] : Springer Science + Business Media B.V, 1976 |g 28(2003), 2, Seite 235-241 |h Online-Ressource |w (DE-627)320587770 |w (DE-600)2018503-0 |w (DE-576)105704679 |x 1573-6903 |7 nnas |a Effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits |
| 773 | 1 | 8 | |g volume:28 |g year:2003 |g number:2 |g pages:235-241 |g extent:7 |a Effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits |
| 856 | 4 | 0 | |u https://doi.org/10.1023/A:1022325116309 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201105 | ||
| 993 | |a Article | ||
| 994 | |a 2003 | ||
| 998 | |g 17213384X |a Henn, Fritz A. |m 17213384X:Henn, Fritz A. |d 60000 |e 60000PH17213384X |k 0/60000/ |p 8 |y j | ||
| 998 | |g 1070544396 |a Herb, Anne |m 1070544396:Herb, Anne |d 700000 |d 712000 |e 700000PH1070544396 |e 712000PH1070544396 |k 0/700000/ |k 1/700000/712000/ |p 5 | ||
| 998 | |g 132388758 |a May, Brigitte |m 132388758:May, Brigitte |d 60000 |e 60000PM132388758 |k 0/60000/ |p 4 | ||
| 998 | |g 121715221 |a Zink, Mathias |m 121715221:Zink, Mathias |d 60000 |e 60000PZ121715221 |k 0/60000/ |p 2 | ||
| 998 | |g 1045120928 |a Schmitt, Andrea |m 1045120928:Schmitt, Andrea |d 60000 |e 60000PS1045120928 |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN173798024X |e 3792668416 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"7 S."}],"relHost":[{"disp":"Effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunitsNeurochemical research","note":["Gesehen am 19.10.05"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"320587770","language":["eng"],"pubHistory":["1.1976 -"],"part":{"extent":"7","text":"28(2003), 2, Seite 235-241","volume":"28","issue":"2","pages":"235-241","year":"2003"},"title":[{"title":"Neurochemical research","title_sort":"Neurochemical research"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"Dordrecht [u.a.] ; New York, NY","dateIssuedKey":"1976","publisher":"Springer Science + Business Media B.V ; Plenum Press","dateIssuedDisp":"1976-"}],"id":{"eki":["320587770"],"zdb":["2018503-0"],"issn":["1573-6903"]}}],"origin":[{"dateIssuedKey":"2003","dateIssuedDisp":"February 2003"}],"id":{"eki":["173798024X"],"doi":["10.1023/A:1022325116309"]},"name":{"displayForm":["Andrea Schmitt, Mathias Zink, Bettina Müller, Brigitte May, Anne Herb, Alexander Jatzko, Dieter F. Braus, and Fritz A. Henn"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 05.11.2020"],"recId":"173798024X","language":["eng"],"title":[{"title_sort":"Effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits","title":"Effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits"}],"person":[{"display":"Schmitt, Andrea","roleDisplay":"VerfasserIn","role":"aut","family":"Schmitt","given":"Andrea"},{"given":"Mathias","family":"Zink","role":"aut","display":"Zink, Mathias","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Müller, Bettina","role":"aut","family":"Müller","given":"Bettina"},{"roleDisplay":"VerfasserIn","display":"May, Brigitte","role":"aut","family":"May","given":"Brigitte"},{"role":"aut","display":"Herb, Anne","roleDisplay":"VerfasserIn","given":"Anne","family":"Herb"},{"display":"Jatzko, Alexander","roleDisplay":"VerfasserIn","role":"aut","family":"Jatzko","given":"Alexander"},{"given":"Dieter F.","family":"Braus","role":"aut","roleDisplay":"VerfasserIn","display":"Braus, Dieter F."},{"roleDisplay":"VerfasserIn","display":"Henn, Fritz A.","role":"aut","family":"Henn","given":"Fritz A."}]} | ||
| SRT | |a SCHMITTANDEFFECTSOFL2003 | ||