Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk
Several studies have reported associations between multiple cancer types and single-nucleotide polymorphisms (SNPs) on chromosome 5p15, which harbours TERT and CLPTM1L, but no such association has been reported with endometrial cancer. To evaluate the role of genetic variants at the TERT-CLPTM1L reg...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2015
|
| In: |
Human genetics
Year: 2014, Volume: 134, Issue: 2, Pages: 231-245 |
| ISSN: | 1432-1203 |
| DOI: | 10.1007/s00439-014-1515-4 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00439-014-1515-4
|
| Author Notes: | Luis G. Carvajal-Carmona, Tracy A. O’Mara, Jodie N. Painter, Felicity A. Lose, Joe Dennis, Kyriaki Michailidou, Jonathan P. Tyrer, Shahana Ahmed, Kaltin Ferguson, Catherine S. Healey, Karen Pooley, Jonathan Beesley, Timothy Cheng, Angela Jones, Kimberley Howarth, Lynn Martin, Maggie Gorman, Shirley Hodgson, Nicholas Wentzensen, Peter A. Fasching, Alexander Hein, Matthias W. Beckmann, Stefan P. Renner, Thilo Dörk, Peter Hillemanns, Matthias Dürst, Ingo Runnebaum, Diether Lambrechts, Lieve Coenegrachts, Stefanie Schrauwen, Frederic Amant, Boris Winterhoff, Sean C. Dowdy, Ellen L. Goode, Attila Teoman, Helga B. Salvesen, Jone Trovik, Tormund S. Njolstad, Henrica M. J. Werner, Rodney J. Scott, Katie Ashton, Tony Proietto, Geoffrey Otton, Ofra Wersäll, Miriam Mints, Emma Tham, Per Hall, Kamila Czene, Jianjun Liu, Jingmei Li, John L. Hopper, Melissa C. Southey, Arif B. Ekici, Matthias Ruebner, Nichola Johnson, Julian Peto, Barbara Burwinkel, Frederik Marme, Hermann Brenner, Aida K. Dieffenbach, Alfons Meindl, Hiltrud Brauch, Annika Lindblom, Jeroen Depreeuw, Matthieu Moisse, Jenny Chang-Claude, Anja Rudolph, Fergus J. Couch, Janet E. Olson, Graham G. Giles, Fiona Bruinsma, Julie M. Cunningham, Brooke L. Fridley, Anne-Lise Børresen-Dale, Vessela N. Kristensen, Angela Cox, Anthony J. Swerdlow, Nicholas Orr, Manjeet K. Bolla, Qin Wang, Rachel Palmieri Weber, Zhihua Chen, Mitul Shah, Paul D. P. Pharoah, Alison M. Dunning, Ian Tomlinson, Douglas F. Easton, Amanda B. Spurdle, Deborah J. Thompson, National Study of Endometrial Cancer Genetics Group (NSECG), The Australian National Endometrial Cancer Study Group (ANECS), RENDOCAS, Australian Ovarian Cancer Study (AOCS), The GENICA Network |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1738018407 | ||
| 003 | DE-627 | ||
| 005 | 20240407193439.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201105r20152014xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00439-014-1515-4 |2 doi | |
| 035 | |a (DE-627)1738018407 | ||
| 035 | |a (DE-599)KXP1738018407 | ||
| 035 | |a (OCoLC)1341375914 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Carvajal-Carmona, Luis G. |e VerfasserIn |0 (DE-627)1494678616 |0 (DE-576)424678616 |4 aut | |
| 245 | 1 | 0 | |a Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk |c Luis G. Carvajal-Carmona, Tracy A. O’Mara, Jodie N. Painter, Felicity A. Lose, Joe Dennis, Kyriaki Michailidou, Jonathan P. Tyrer, Shahana Ahmed, Kaltin Ferguson, Catherine S. Healey, Karen Pooley, Jonathan Beesley, Timothy Cheng, Angela Jones, Kimberley Howarth, Lynn Martin, Maggie Gorman, Shirley Hodgson, Nicholas Wentzensen, Peter A. Fasching, Alexander Hein, Matthias W. Beckmann, Stefan P. Renner, Thilo Dörk, Peter Hillemanns, Matthias Dürst, Ingo Runnebaum, Diether Lambrechts, Lieve Coenegrachts, Stefanie Schrauwen, Frederic Amant, Boris Winterhoff, Sean C. Dowdy, Ellen L. Goode, Attila Teoman, Helga B. Salvesen, Jone Trovik, Tormund S. Njolstad, Henrica M. J. Werner, Rodney J. Scott, Katie Ashton, Tony Proietto, Geoffrey Otton, Ofra Wersäll, Miriam Mints, Emma Tham, Per Hall, Kamila Czene, Jianjun Liu, Jingmei Li, John L. Hopper, Melissa C. Southey, Arif B. Ekici, Matthias Ruebner, Nichola Johnson, Julian Peto, Barbara Burwinkel, Frederik Marme, Hermann Brenner, Aida K. Dieffenbach, Alfons Meindl, Hiltrud Brauch, Annika Lindblom, Jeroen Depreeuw, Matthieu Moisse, Jenny Chang-Claude, Anja Rudolph, Fergus J. Couch, Janet E. Olson, Graham G. Giles, Fiona Bruinsma, Julie M. Cunningham, Brooke L. Fridley, Anne-Lise Børresen-Dale, Vessela N. Kristensen, Angela Cox, Anthony J. Swerdlow, Nicholas Orr, Manjeet K. Bolla, Qin Wang, Rachel Palmieri Weber, Zhihua Chen, Mitul Shah, Paul D. P. Pharoah, Alison M. Dunning, Ian Tomlinson, Douglas F. Easton, Amanda B. Spurdle, Deborah J. Thompson, National Study of Endometrial Cancer Genetics Group (NSECG), The Australian National Endometrial Cancer Study Group (ANECS), RENDOCAS, Australian Ovarian Cancer Study (AOCS), The GENICA Network |
| 264 | 1 | |c 2015 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.11.2020 | ||
| 520 | |a Several studies have reported associations between multiple cancer types and single-nucleotide polymorphisms (SNPs) on chromosome 5p15, which harbours TERT and CLPTM1L, but no such association has been reported with endometrial cancer. To evaluate the role of genetic variants at the TERT-CLPTM1L region in endometrial cancer risk, we carried out comprehensive fine-mapping analyses of genotyped and imputed SNPs using a custom Illumina iSelect array which includes dense SNP coverage of this region. We examined 396 SNPs (113 genotyped, 283 imputed) in 4,401 endometrial cancer cases and 28,758 controls. Single-SNP and forward/backward logistic regression models suggested evidence for three variants independently associated with endometrial cancer risk (P = 4.9 × 10−6 to P = 7.7 × 10−5). Only one falls into a haplotype previously associated with other cancer types (rs7705526, in TERT intron 1), and this SNP has been shown to alter TERT promoter activity. One of the novel associations (rs13174814) maps to a second region in the TERT promoter and the other (rs62329728) is in the promoter region of CLPTM1L; neither are correlated with previously reported cancer-associated SNPs. Using TCGA RNASeq data, we found significantly increased expression of both TERT and CLPTM1L in endometrial cancer tissue compared with normal tissue (TERTP = 1.5 × 10−18, CLPTM1LP = 1.5 × 10−19). Our study thus reports a novel endometrial cancer risk locus and expands the spectrum of cancer types associated with genetic variation at 5p15, further highlighting the importance of this region for cancer susceptibility. | ||
| 534 | |c 2014 | ||
| 700 | 1 | |a Burwinkel, Barbara |d 1969- |e VerfasserIn |0 (DE-588)120685760 |0 (DE-627)704924005 |0 (DE-576)292337752 |4 aut | |
| 700 | 1 | |a Marmé, Frederik |d 1974- |e VerfasserIn |0 (DE-588)132561972 |0 (DE-627)52394893X |0 (DE-576)299226549 |4 aut | |
| 700 | 1 | |a Brenner, Hermann |e VerfasserIn |0 (DE-588)1020516445 |0 (DE-627)691247005 |0 (DE-576)360642136 |4 aut | |
| 700 | 1 | |a Dieffenbach, Aida Karina |d 1983- |e VerfasserIn |0 (DE-588)1019645989 |0 (DE-627)685507920 |0 (DE-576)358521718 |4 aut | |
| 700 | 1 | |a Chang-Claude, Jenny |e VerfasserIn |0 (DE-588)1049304993 |0 (DE-627)781626188 |0 (DE-576)168344475 |4 aut | |
| 700 | 1 | |a Rudolph, Anja |d 1982- |e VerfasserIn |0 (DE-588)1030064202 |0 (DE-627)735177910 |0 (DE-576)377876356 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Human genetics |d Berlin : Springer, 1976 |g 134(2015), 2, Seite 231-245 |h Online-Ressource |w (DE-627)253723973 |w (DE-600)1459188-1 |w (DE-576)072373008 |x 1432-1203 |7 nnas |a Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk |
| 773 | 1 | 8 | |g volume:134 |g year:2015 |g number:2 |g pages:231-245 |g extent:15 |a Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |a Carvajal-Carmona, Luis G. |t Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk |d 2015 |w (DE-627)1641788100 |w (DE-576)42467890X |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00439-014-1515-4 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201105 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1030064202 |a Rudolph, Anja |m 1030064202:Rudolph, Anja |d 50000 |e 50000PR1030064202 |k 0/50000/ |p 67 | ||
| 998 | |g 1049304993 |a Chang-Claude, Jenny |m 1049304993:Chang-Claude, Jenny |d 50000 |e 50000PC1049304993 |k 0/50000/ |p 66 | ||
| 998 | |g 1019645989 |a Dieffenbach, Aida Karina |m 1019645989:Dieffenbach, Aida Karina |d 50000 |e 50000PD1019645989 |k 0/50000/ |p 60 | ||
| 998 | |g 1020516445 |a Brenner, Hermann |m 1020516445:Brenner, Hermann |d 850000 |d 851600 |d 50000 |e 850000PB1020516445 |e 851600PB1020516445 |e 50000PB1020516445 |k 0/850000/ |k 1/850000/851600/ |k 0/50000/ |p 59 | ||
| 998 | |g 132561972 |a Marmé, Frederik |m 132561972:Marmé, Frederik |d 910000 |d 910400 |e 910000PM132561972 |e 910400PM132561972 |k 0/910000/ |k 1/910000/910400/ |p 58 | ||
| 998 | |g 120685760 |a Burwinkel, Barbara |m 120685760:Burwinkel, Barbara |d 910000 |d 910400 |e 910000PB120685760 |e 910400PB120685760 |k 0/910000/ |k 1/910000/910400/ |p 57 | ||
| 999 | |a KXP-PPN1738018407 |e 3792768879 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1007/s00439-014-1515-4"],"eki":["1738018407"]},"recId":"1738018407","relHost":[{"disp":"Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer riskHuman genetics","type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["Volume 31, issue 1 (January 1976)-"],"note":["Gesehen am 27.01.25","Ungezählte Beil.: Supplement"],"origin":[{"publisherPlace":"Berlin ; Heidelberg ; Berlin ; Heidelberg ; New York, NY","publisher":"Springer ; Springer","dateIssuedKey":"1976","dateIssuedDisp":"1976-"}],"title":[{"title":"Human genetics","title_sort":"Human genetics"}],"id":{"eki":["253723973"],"issn":["1432-1203"],"zdb":["1459188-1"]},"physDesc":[{"extent":"Online-Ressource"}],"recId":"253723973","titleAlt":[{"title":"Human genetics <Berlin>"}],"part":{"volume":"134","extent":"15","pages":"231-245","year":"2015","text":"134(2015), 2, Seite 231-245","issue":"2"},"language":["eng"]}],"name":{"displayForm":["Luis G. Carvajal-Carmona, Tracy A. O’Mara, Jodie N. Painter, Felicity A. Lose, Joe Dennis, Kyriaki Michailidou, Jonathan P. Tyrer, Shahana Ahmed, Kaltin Ferguson, Catherine S. Healey, Karen Pooley, Jonathan Beesley, Timothy Cheng, Angela Jones, Kimberley Howarth, Lynn Martin, Maggie Gorman, Shirley Hodgson, Nicholas Wentzensen, Peter A. Fasching, Alexander Hein, Matthias W. Beckmann, Stefan P. Renner, Thilo Dörk, Peter Hillemanns, Matthias Dürst, Ingo Runnebaum, Diether Lambrechts, Lieve Coenegrachts, Stefanie Schrauwen, Frederic Amant, Boris Winterhoff, Sean C. Dowdy, Ellen L. Goode, Attila Teoman, Helga B. Salvesen, Jone Trovik, Tormund S. Njolstad, Henrica M. J. Werner, Rodney J. Scott, Katie Ashton, Tony Proietto, Geoffrey Otton, Ofra Wersäll, Miriam Mints, Emma Tham, Per Hall, Kamila Czene, Jianjun Liu, Jingmei Li, John L. Hopper, Melissa C. Southey, Arif B. Ekici, Matthias Ruebner, Nichola Johnson, Julian Peto, Barbara Burwinkel, Frederik Marme, Hermann Brenner, Aida K. Dieffenbach, Alfons Meindl, Hiltrud Brauch, Annika Lindblom, Jeroen Depreeuw, Matthieu Moisse, Jenny Chang-Claude, Anja Rudolph, Fergus J. Couch, Janet E. Olson, Graham G. Giles, Fiona Bruinsma, Julie M. Cunningham, Brooke L. Fridley, Anne-Lise Børresen-Dale, Vessela N. Kristensen, Angela Cox, Anthony J. Swerdlow, Nicholas Orr, Manjeet K. Bolla, Qin Wang, Rachel Palmieri Weber, Zhihua Chen, Mitul Shah, Paul D. P. Pharoah, Alison M. Dunning, Ian Tomlinson, Douglas F. Easton, Amanda B. Spurdle, Deborah J. Thompson, National Study of Endometrial Cancer Genetics Group (NSECG), The Australian National Endometrial Cancer Study Group (ANECS), RENDOCAS, Australian Ovarian Cancer Study (AOCS), The GENICA Network"]},"physDesc":[{"extent":"15 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"2015","dateIssuedKey":"2015"}],"note":["Gesehen am 05.11.2020"],"title":[{"title":"Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk","title_sort":"Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk"}],"language":["eng"],"person":[{"display":"Carvajal-Carmona, Luis G.","family":"Carvajal-Carmona","role":"aut","given":"Luis G."},{"given":"Barbara","role":"aut","family":"Burwinkel","display":"Burwinkel, Barbara"},{"role":"aut","given":"Frederik","display":"Marmé, Frederik","family":"Marmé"},{"given":"Hermann","role":"aut","display":"Brenner, Hermann","family":"Brenner"},{"given":"Aida Karina","role":"aut","display":"Dieffenbach, Aida Karina","family":"Dieffenbach"},{"role":"aut","given":"Jenny","family":"Chang-Claude","display":"Chang-Claude, Jenny"},{"family":"Rudolph","display":"Rudolph, Anja","given":"Anja","role":"aut"}]} | ||
| SRT | |a CARVAJALCACANDIDATEL2015 | ||