MAP1S controls microtubule stability throughout the cell cycle in human cells
Understanding the molecular basis for proper cell division requires a detailed functional analysis of microtubule (MT)-associated proteins. MT-associated protein 1S (MAP1S), the most ubiquitously expressed MAP1 family member, is required for accurate cell division. Here, using quantitative analysis...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 30, 2014
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| In: |
Journal of cell science
Year: 2014, Jahrgang: 127, Heft: 23, Pages: 5007-5013 |
| ISSN: | 1477-9137 |
| DOI: | 10.1242/jcs.136457 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1242/jcs.136457 Verlag, lizenzpflichtig, Volltext: https://jcs.biologists.org/content/127/23/5007 
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| Verfasserangaben: | Justus Tegha-Dunghu, Elena Bausch, Beate Neumann, Annelie Wuensche, Thomas Walter, Jan Ellenberg and Oliver J. Gruss |
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| 520 | |a Understanding the molecular basis for proper cell division requires a detailed functional analysis of microtubule (MT)-associated proteins. MT-associated protein 1S (MAP1S), the most ubiquitously expressed MAP1 family member, is required for accurate cell division. Here, using quantitative analysis of MT plus-end tracking, we show that MAP1S knockdown alters MT dynamics throughout the cell cycle. Surprisingly, MAP1S downregulation results in faster growing, yet short-lived, MTs in all cell cycle stages and in a global loss of MT acetylation. These aberrations correlate with severe defects in the final stages of cell division. In monopolar cytokinesis assays, we demonstrate that MAP1S guides MT-dependent initiation of cytokinesis. Our data underline the key role of MAP1S as a global regulator of MT stability and demonstrate a new primary function of MAP1S to regulate MT dynamics at the onset of cytokinesis. | ||
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