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Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter

Major depression is conditionally linked to a polymorphism of the human serotonin transporter gene (SLC6A4). During the presentation of aversive, but not pleasant, pictures, healthy carriers of the SLC6A4 short (s) allele showed stronger activation of the amygdala on functional magnetic resonance im...

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Main Authors: Heinz, Andreas (Author) , Braus, Dieter F. (Author) , Smolka, Michael (Author) , Wrase, Jana (Author) , Puls, Imke (Author) , Hermann, Derik (Author) , Vollstädt-Klein, Sabine (Author) , Grüsser, Sabine M. (Author) , Flor, Herta (Author) , Schumann, Gunter (Author) , Mann, Karl (Author) , Büchel, Christian (Author)
Format: Article (Journal)
Language:English
Published: 2005
In: Nature neuroscience
Year: 2004, Volume: 8, Issue: 1, Pages: 20-21
ISSN:1546-1726
DOI:10.1038/nn1366
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nn1366
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nn1366
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Author Notes:Andreas Heinz, Dieter F. Braus, Michael N. Smolka, Jana Wrase, Imke Puls, Derik Hermann, Sabine Klein, Sabine M. Grüsser, Herta Flor, Gunter Schumann, Karl Mann, Christian Büchel
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Summary:Major depression is conditionally linked to a polymorphism of the human serotonin transporter gene (SLC6A4). During the presentation of aversive, but not pleasant, pictures, healthy carriers of the SLC6A4 short (s) allele showed stronger activation of the amygdala on functional magnetic resonance imaging. s carriers also showed greater coupling between the amygdala and the ventromedial prefrontal cortex, which may contribute to the abnormally high activity in the amygdala and medial prefrontal cortex seen in major depression.
Item Description:Published online 12 December 2004
Gesehen am 09.11.2020
Physical Description:Online Resource
ISSN:1546-1726
DOI:10.1038/nn1366

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