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Functioning and neuronal viability of the anterior cingulate neurons following antipsychotic treatment: MR-spectroscopic imaging in chronic schizophrenia

Magnetic resonance spectroscopic imaging provides a non-invasive approach for testing the hypothesis that neuronal function can improve under atypical antipsychotic medication leading to improvement in cognitive function. We studied two groups of schizophrenic patients, one treated exclusively with...

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Hauptverfasser: Braus, Dieter F. (VerfasserIn) , Ende, Gabriele (VerfasserIn) , Weber-Fahr, Wolfgang (VerfasserIn) , Demirakça, Traute (VerfasserIn) , Tost, Heike (VerfasserIn) , Henn, Fritz A. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 17 January 2002
In: European neuropsychopharmacology
Year: 2002, Jahrgang: 12, Heft: 2, Pages: 145-152
ISSN:1873-7862
DOI:10.1016/S0924-977X(02)00003-2
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0924-977X(02)00003-2
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0924977X02000032
Volltext
Verfasserangaben:Dieter F Braus, Gabriele Ende, Wolfgang Weber-Fahr, Traute Demirakca, Heike Tost, Fritz A Henn
Beschreibung
Zusammenfassung:Magnetic resonance spectroscopic imaging provides a non-invasive approach for testing the hypothesis that neuronal function can improve under atypical antipsychotic medication leading to improvement in cognitive function. We studied two groups of schizophrenic patients, one treated exclusively with typical neuroleptics, the other with atypical medications. 1H MR-spectroscopic imaging of the anterior cingulate gyrus was performed in all patients. Perseveration errors in the Wisconsin Card Sorting Test (WCST) served as an additional marker for cingulate gyrus function. Our results showed that N-acetylaspartate (NAA), a measure of neuronal function, was closely correlated with perseveration errors seen on the WCST. Patients treated with atypical medications had fewer errors on the WCST and higher NAA levels than those on typical medications, and there was a correlation between the time treated with atypical medication, higher NAA levels and better test performance. These results suggest that atypical antipsychotics modify the function of anterior cingulate neurons in a specific manner.
Beschreibung:Gesehen am 09.11.2020
Beschreibung:Online Resource
ISSN:1873-7862
DOI:10.1016/S0924-977X(02)00003-2

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