Inhibition of overexpressed Kv3.4 augments HPV in endotoxemic mice
Hypoxic pulmonary vasoconstriction (HPV) is a reaction of the pulmonary vasculature upon hypoxia, diverting blood flow into ventilated areas to preserve oxygenation. It is impaired in endotoxemia or ARDS. Voltage gated potassium channels have been shown to play a key role in the regulation of HPV. T...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
08 October 2020
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| In: |
BMC pulmonary medicine
Year: 2020, Jahrgang: 20 |
| ISSN: | 1471-2466 |
| DOI: | 10.1186/s12890-020-01278-5 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12890-020-01278-5
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| Verfasserangaben: | Maurizio Turzo, Karin Metzger, Felix Lasitschka, Markus A. Weigand and Cornelius J. Busch |
| Zusammenfassung: | Hypoxic pulmonary vasoconstriction (HPV) is a reaction of the pulmonary vasculature upon hypoxia, diverting blood flow into ventilated areas to preserve oxygenation. It is impaired in endotoxemia or ARDS. Voltage gated potassium channels have been shown to play a key role in the regulation of HPV. The aim of the study was to identify a voltage gated potassium channel involved in dysregulated HPV during endotoxemia. |
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| Beschreibung: | Gesehen am 09.11.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1471-2466 |
| DOI: | 10.1186/s12890-020-01278-5 |