ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia
Different studies have investigated the effect of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the risk of Alzheimer dementia (AD). However, results on the association of the ACE-I allele with AD have been inconclusive. A recent meta-analysis reported an associati...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2005
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| In: |
Neuroscience letters
Year: 2004, Jahrgang: 377, Heft: 1, Pages: 37-39 |
| ISSN: | 1872-7972 |
| DOI: | 10.1016/j.neulet.2004.11.062 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neulet.2004.11.062 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0304394004014776 
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| Verfasserangaben: | H. Kölsch, F. Jessen, N. Freymann, M. Kreis, F. Hentschel, W. Maier, R. Heun |
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| 245 | 1 | 0 | |a ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia |c H. Kölsch, F. Jessen, N. Freymann, M. Kreis, F. Hentschel, W. Maier, R. Heun |
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| 520 | |a Different studies have investigated the effect of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the risk of Alzheimer dementia (AD). However, results on the association of the ACE-I allele with AD have been inconclusive. A recent meta-analysis reported an association of the I-allele with the risk of AD. A few small studies also investigated the effect of ACE polymorphism on the risk of vascular dementia (VD). We have investigated the effect of ACE I/D polymorphism in 351 AD and 155 VD patients and 348 healthy controls. We found the I/I genotype to be associated with an increased risk of AD, but not with the risk of VD. Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD. | ||
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| 650 | 4 | |a Alzheimer's disease | |
| 650 | 4 | |a Angiotensin converting enzyme | |
| 650 | 4 | |a Association | |
| 650 | 4 | |a Polymorphism | |
| 650 | 4 | |a Vascular dementia | |
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| 700 | 1 | |a Freymann, N. |e VerfasserIn |4 aut | |
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