Carbon ion radiotherapy as definitive treatment in non-metastasized pancreatic cancer: study protocol of the prospective phase II PACK-study
Radiotherapy is known to improve local tumor control in locally advanced pancreatic cancer (LAPC), although there is a lack of convincing data on a potential overall survival benefit of chemoradiotherapy over chemotherapy alone. To improve efficacy of radiotherapy, new approaches need to be evolved....
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 October 2020
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| In: |
BMC cancer
Year: 2020, Volume: 20 |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/s12885-020-07434-8 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12885-020-07434-8
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| Author Notes: | Jakob Liermann, Patrick Naumann, Adriane Hommertgen, Moritz Pohl, Meinhard Kieser, Juergen Debus and Klaus Herfarth |
| Summary: | Radiotherapy is known to improve local tumor control in locally advanced pancreatic cancer (LAPC), although there is a lack of convincing data on a potential overall survival benefit of chemoradiotherapy over chemotherapy alone. To improve efficacy of radiotherapy, new approaches need to be evolved. Carbon ion radiotherapy is supposed to be more effective than photon radiotherapy due to a higher relative biological effectiveness (RBE) and due to a steep dose-gradient making dose delivery highly conformal. |
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| Item Description: | Gesehen am 10.11.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/s12885-020-07434-8 |