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Carbon ion radiotherapy as definitive treatment in non-metastasized pancreatic cancer: study protocol of the prospective phase II PACK-study

Radiotherapy is known to improve local tumor control in locally advanced pancreatic cancer (LAPC), although there is a lack of convincing data on a potential overall survival benefit of chemoradiotherapy over chemotherapy alone. To improve efficacy of radiotherapy, new approaches need to be evolved....

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Hauptverfasser: Liermann, Jakob (VerfasserIn) , Naumann, Patrick (VerfasserIn) , Hommertgen, Adriane (VerfasserIn) , Pohl, Moritz (VerfasserIn) , Kieser, Meinhard (VerfasserIn) , Debus, Jürgen (VerfasserIn) , Herfarth, Klaus (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 01 October 2020
In: BMC cancer
Year: 2020, Jahrgang: 20
ISSN:1471-2407
DOI:10.1186/s12885-020-07434-8
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12885-020-07434-8
Volltext
Verfasserangaben:Jakob Liermann, Patrick Naumann, Adriane Hommertgen, Moritz Pohl, Meinhard Kieser, Juergen Debus and Klaus Herfarth
Beschreibung
Zusammenfassung:Radiotherapy is known to improve local tumor control in locally advanced pancreatic cancer (LAPC), although there is a lack of convincing data on a potential overall survival benefit of chemoradiotherapy over chemotherapy alone. To improve efficacy of radiotherapy, new approaches need to be evolved. Carbon ion radiotherapy is supposed to be more effective than photon radiotherapy due to a higher relative biological effectiveness (RBE) and due to a steep dose-gradient making dose delivery highly conformal.
Beschreibung:Gesehen am 10.11.2020
Beschreibung:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-020-07434-8

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