Associations of urinary 8-iso-prostaglandin F2α levels with all-cause dementia, Alzheimer's disease, and vascular dementia incidence: results from a prospective cohort study
Introduction Prospective studies on a potential association of 8-iso-prostaglandin F2α (8-iso-PGF2α) levels, a biomarker of lipid peroxidation, with dementia are limited. Methods Multivariate Cox regression models were used to assess potential associations of urinary 8-iso-PGF2α levels with all-caus...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
12 April 2020
|
| In: |
Alzheimer's and dementia
Year: 2020, Jahrgang: 16, Heft: 5, Pages: 804-813 |
| ISSN: | 1552-5279 |
| DOI: | https://doi.org/10.1002/alz.12081 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1002/alz.12081 Verlag, lizenzpflichtig, Volltext: https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.12081 
|
| Verfasserangaben: | Kira Trares, Xīn Gào, Laura Perna, Dan Rujescu, Hannah Stocker, Tobias Möllers, Konrad Beyreuther, Hermann Brenner, Ben Schöttker |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1738318966 | ||
| 003 | DE-627 | ||
| 005 | 20230428161340.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201110s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/alz.12081 |2 doi | |
| 035 | |a (DE-627)1738318966 | ||
| 035 | |a (DE-599)KXP1738318966 | ||
| 035 | |a (OCoLC)1341375289 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Trares, Kira |d 1994- |e VerfasserIn |0 (DE-588)1221159763 |0 (DE-627)1738319326 |4 aut | |
| 245 | 1 | 0 | |a Associations of urinary 8-iso-prostaglandin F2α levels with all-cause dementia, Alzheimer's disease, and vascular dementia incidence |b results from a prospective cohort study |c Kira Trares, Xīn Gào, Laura Perna, Dan Rujescu, Hannah Stocker, Tobias Möllers, Konrad Beyreuther, Hermann Brenner, Ben Schöttker |
| 246 | 3 | 3 | |a Associations of urinary 8-iso-prostaglandin F2 alpha levels with all-cause dementia, Alzheimer's disease, and vascular dementia incidence$dresults from a prospective cohort study |
| 264 | 1 | |c 12 April 2020 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Im Titel ist "2α" tiefgestellt | ||
| 500 | |a Gesehen am 10.11.2020 | ||
| 520 | |a Introduction Prospective studies on a potential association of 8-iso-prostaglandin F2α (8-iso-PGF2α) levels, a biomarker of lipid peroxidation, with dementia are limited. Methods Multivariate Cox regression models were used to assess potential associations of urinary 8-iso-PGF2α levels with all-cause, Alzheimer's disease (AD), and vascular dementia (VD) incidence in 5853 older adults from a German, population-based cohort. Results Over 14 years of follow-up, 365 all-cause dementia cases including 127 VD and 109 AD cases were diagnosed. Participants in the top compared to the bottom 8-iso-PGF2α tertile had a 45% increased risk of all-cause dementia incidence (hazard ratio [95% confidence interval]: 1.45 [1.12 to 1.88]). Interaction with the apolipoprotein E (APOE) ԑ4/ԑ4 genotype was detected (P = .02). Furthermore, continuously modeled, logarithmized 8-iso-PGF2α levels were statistically significantly associated with all-cause dementia and AD incidence. Discussion Oxidative stress may be involved in the pathogenesis of dementia. Individuals with increased 8-iso-PGF2α levels and the APOE ԑ4/ԑ4 genotype showed a considerably increased dementia risk. | ||
| 650 | 4 | |a 8-iso-prostaglandin F2α | |
| 650 | 4 | |a Alzheimer's disease | |
| 650 | 4 | |a cohort study | |
| 650 | 4 | |a dementia | |
| 650 | 4 | |a oxidative stress | |
| 650 | 4 | |a vascular dementia | |
| 700 | 1 | |a Gào, Xīn |e VerfasserIn |4 aut | |
| 700 | 1 | |a Perna, Laura |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rujescu, Dan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stocker, Hannah |d 1990- |e VerfasserIn |0 (DE-588)116628199X |0 (DE-627)1030292507 |0 (DE-576)510710271 |4 aut | |
| 700 | 1 | |a Möllers, Tobias |d 1990- |e VerfasserIn |0 (DE-588)1165087197 |0 (DE-627)1029274975 |0 (DE-576)510241336 |4 aut | |
| 700 | 1 | |a Beyreuther, Konrad |d 1941- |e VerfasserIn |0 (DE-588)133652580 |0 (DE-627)550295852 |0 (DE-576)299999424 |4 aut | |
| 700 | 1 | |a Brenner, Hermann |e VerfasserIn |0 (DE-588)1020516445 |0 (DE-627)691247005 |0 (DE-576)360642136 |4 aut | |
| 700 | 1 | |a Schöttker, Ben |e VerfasserIn |0 (DE-588)138862443 |0 (DE-627)703132423 |0 (DE-576)309375657 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Alzheimer's and dementia |d Hoboken, NJ : Wiley, 2005 |g 16(2020), 5, Seite 804-813 |h Online-Ressource |w (DE-627)499546059 |w (DE-600)2201940-6 |w (DE-576)255666330 |x 1552-5279 |7 nnas |a Associations of urinary 8-iso-prostaglandin F2α levels with all-cause dementia, Alzheimer's disease, and vascular dementia incidence results from a prospective cohort study |
| 773 | 1 | 8 | |g volume:16 |g year:2020 |g number:5 |g pages:804-813 |g extent:10 |a Associations of urinary 8-iso-prostaglandin F2α levels with all-cause dementia, Alzheimer's disease, and vascular dementia incidence results from a prospective cohort study |
| 856 | 4 | 0 | |u https://doi.org/https://doi.org/10.1002/alz.12081 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.12081 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201110 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 138862443 |a Schöttker, Ben |m 138862443:Schöttker, Ben |d 850000 |d 851600 |d 50000 |e 850000PS138862443 |e 851600PS138862443 |e 50000PS138862443 |k 0/850000/ |k 1/850000/851600/ |k 0/50000/ |p 9 |y j | ||
| 998 | |g 1020516445 |a Brenner, Hermann |m 1020516445:Brenner, Hermann |d 850000 |d 851600 |d 50000 |e 850000PB1020516445 |e 851600PB1020516445 |e 50000PB1020516445 |k 0/850000/ |k 1/850000/851600/ |k 0/50000/ |p 8 | ||
| 998 | |g 133652580 |a Beyreuther, Konrad |m 133652580:Beyreuther, Konrad |d 850000 |d 851600 |d 50000 |e 850000PB133652580 |e 851600PB133652580 |e 50000PB133652580 |k 0/850000/ |k 1/850000/851600/ |k 0/50000/ |p 7 | ||
| 998 | |g 1165087197 |a Möllers, Tobias |m 1165087197:Möllers, Tobias |d 850000 |d 851600 |d 50000 |e 850000PM1165087197 |e 851600PM1165087197 |e 50000PM1165087197 |k 0/850000/ |k 1/850000/851600/ |k 0/50000/ |p 6 | ||
| 998 | |g 116628199X |a Stocker, Hannah |m 116628199X:Stocker, Hannah |p 5 | ||
| 998 | |g 1221159763 |a Trares, Kira |m 1221159763:Trares, Kira |d 50000 |e 50000PT1221159763 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1738318966 |e 3796368190 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"note":["Gesehen am 19.03.2024"],"pubHistory":["1.2005 -"],"recId":"499546059","disp":"Associations of urinary 8-iso-prostaglandin F2α levels with all-cause dementia, Alzheimer's disease, and vascular dementia incidence results from a prospective cohort studyAlzheimer's and dementia","part":{"text":"16(2020), 5, Seite 804-813","pages":"804-813","volume":"16","issue":"5","extent":"10","year":"2020"},"title":[{"title_sort":"Alzheimer's and dementia","subtitle":"the journal of the Alzheimer's Association","title":"Alzheimer's and dementia"}],"physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"id":{"zdb":["2201940-6"],"issn":["1552-5279"],"eki":["499546059"],"doi":["10.1002/(ISSN)1552-5279"]},"language":["eng"],"origin":[{"publisherPlace":"Hoboken, NJ ; Amsterdam","dateIssuedDisp":"2005-","dateIssuedKey":"2005","publisher":"Wiley ; Elsevier"}]}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"id":{"eki":["1738318966"],"doi":["10.1002/alz.12081"]},"person":[{"role":"aut","given":"Kira","family":"Trares","display":"Trares, Kira"},{"given":"Xīn","display":"Gào, Xīn","family":"Gào","role":"aut"},{"family":"Perna","display":"Perna, Laura","given":"Laura","role":"aut"},{"role":"aut","display":"Rujescu, Dan","family":"Rujescu","given":"Dan"},{"given":"Hannah","family":"Stocker","display":"Stocker, Hannah","role":"aut"},{"given":"Tobias","family":"Möllers","display":"Möllers, Tobias","role":"aut"},{"role":"aut","given":"Konrad","display":"Beyreuther, Konrad","family":"Beyreuther"},{"given":"Hermann","display":"Brenner, Hermann","family":"Brenner","role":"aut"},{"given":"Ben","family":"Schöttker","display":"Schöttker, Ben","role":"aut"}],"physDesc":[{"extent":"10 S."}],"title":[{"title":"Associations of urinary 8-iso-prostaglandin F2α levels with all-cause dementia, Alzheimer's disease, and vascular dementia incidence","subtitle":"results from a prospective cohort study","title_sort":"Associations of urinary 8-iso-prostaglandin F2α levels with all-cause dementia, Alzheimer's disease, and vascular dementia incidence"}],"titleAlt":[{"title":"Associations of urinary 8-iso-prostaglandin F2 alpha levels with all-cause dementia, Alzheimer's disease, and vascular dementia incidence$dresults from a prospective cohort study"}],"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"12 April 2020"}],"name":{"displayForm":["Kira Trares, Xīn Gào, Laura Perna, Dan Rujescu, Hannah Stocker, Tobias Möllers, Konrad Beyreuther, Hermann Brenner, Ben Schöttker"]},"recId":"1738318966","note":["Im Titel ist \"2α\" tiefgestellt","Gesehen am 10.11.2020"]} | ||
| SRT | |a TRARESKIRAASSOCIATIO1220 | ||