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Segregation of effector mechanisms in a tumour-specific CD8+ t-cell clone correlates with CD30 expression

In this study we have analyzed CD30-antigen expression in three melanoma-directed cytotoxic T lymphocyte (CTL) clones with a T helper 0 (Th0)-like cytokine secretion profile (i.e. interleukin (IL)-4, IL-5, and interferon (IFN)-γ). We show that all CTL clones expressed high levels of CD30 upon contac...

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Hauptverfasser: Sun, Yuansheng (VerfasserIn) , Song, Mingxia (VerfasserIn) , Schadendorf, Dirk (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 23 December 2001
In: Scandinavian journal of immunology
Year: 2001, Jahrgang: 54, Heft: 3, Pages: 314-320
ISSN:1365-3083
DOI:https://doi.org/10.1046/j.1365-3083.2001.00971.x
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1046/j.1365-3083.2001.00971.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-3083.2001.00971.x
Volltext
Verfasserangaben:Y. Sun, M. Song, M.J. Maeurer & D. Schadendorf
Beschreibung
Zusammenfassung:In this study we have analyzed CD30-antigen expression in three melanoma-directed cytotoxic T lymphocyte (CTL) clones with a T helper 0 (Th0)-like cytokine secretion profile (i.e. interleukin (IL)-4, IL-5, and interferon (IFN)-γ). We show that all CTL clones expressed high levels of CD30 upon contact with the autologous tumour cells. One CTL clone, termed A2 with a monoclonal feature was selected for further analyses and found its CD30 expression dependent on the presence of IL-4. Functionally, a CD30-expressing A2 CTL was capable of producing higher amounts of IFN-γ (up to 1.5-fold) and IL-4 (up to two-fold) than its CD30− counterpart. Furthermore, CD30-positive A2 CTL displayed an at least three-fold greater proliferative response to the tumour cell stimulation, contrasting with CD30− CTL. However, the antitumour cytotoxic activity of A2 CTL was not modulated by the CD30 expression. These results suggest that CD30 antigen can be inducible on a subset of tumour-directed CD8+ CTL, and that this subset of cells may have profound effector functions, such as cytokine secretion, proliferation, and cytotoxicity.
Beschreibung:Gesehen am 10.11.2020
Beschreibung:Online Resource
ISSN:1365-3083
DOI:https://doi.org/10.1046/j.1365-3083.2001.00971.x

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