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The role of endothelin-1 in the sympathetic nervous system in the heart

Endothelin-1 (ET1) is a peptide that was initially identified as a strong inductor of vascular contraction. In the last 25 years, there have been several biological processes identified in which ET1 seems to play a critical role. In particular, genetic studies have unveiled that ET1 is important for...

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Bibliographische Detailangaben
Hauptverfasser: Lehmann, Lorenz (VerfasserIn) , Stanmore, David (VerfasserIn) , Backs, Johannes (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 13 March 2014
In: Life sciences
Year: 2014, Jahrgang: 118, Heft: 2, Pages: 165-172
ISSN:1879-0631
DOI:10.1016/j.lfs.2014.03.005
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.lfs.2014.03.005
Volltext
Verfasserangaben:Lorenz H. Lehmann, David A. Stanmore, Johannes Backs

MARC

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520 |a Endothelin-1 (ET1) is a peptide that was initially identified as a strong inductor of vascular contraction. In the last 25 years, there have been several biological processes identified in which ET1 seems to play a critical role. In particular, genetic studies have unveiled that ET1 is important for neuronal development, growth and function. Experimental studies identified ET1 as a regulator of the interaction between sympathetic neurons and cardiac myocytes. This might be of clinical importance since patients suffering from heart failure are characterized by disrupted norepinephrine homeostasis in the heart. This review summarizes the important findings on the role of ET1 for sympathetic neurons and norepinephrine homeostasis in the heart. 
650 4 |a Animals 
650 4 |a Endothelin 
650 4 |a Endothelin Receptor Antagonists 
650 4 |a Endothelin-1 
650 4 |a Heart failure 
650 4 |a Humans 
650 4 |a Myocardium 
650 4 |a Norepinephrine 
650 4 |a Receptors, Endothelin 
650 4 |a Signal Transduction 
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650 4 |a Sympathetic Nervous System 
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