Mechanisms of depression: the role of neurogenesis
The behavioral changes in depression can relate to alterations in hippocampal function. A variety of inputs to the hippocampus can effect mood, including norepinephrine (NE), serotonin (5HT) and cortisol, all factors activated by stress. These are thought to act through activation of CREB and neurot...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
26 November 2004
|
| In: |
Drug discovery today. Disease mechanisms
Year: 2004, Volume: 1, Issue: 4, Pages: 407-411 |
| ISSN: | 1740-6765 |
| DOI: | 10.1016/j.ddmec.2004.10.007 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ddmec.2004.10.007 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1740676504000483 
|
| Author Notes: | Fritz Henn, Barbara Vollmayr, Alexander Sartorius |
| Summary: | The behavioral changes in depression can relate to alterations in hippocampal function. A variety of inputs to the hippocampus can effect mood, including norepinephrine (NE), serotonin (5HT) and cortisol, all factors activated by stress. These are thought to act through activation of CREB and neurotrophins such as BDNF. Stress has been shown to decrease hippocampal neurogenesis and most antidepressants increase neurogenesis, leading to the hypothesis that changes in the rate of new neuron formation might underlie depressive illnesses. |
|---|---|
| Item Description: | Gesehen am 10.11.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1740-6765 |
| DOI: | 10.1016/j.ddmec.2004.10.007 |