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Vitamin D deficiency and outcome of COVID-19 patients

Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses an enormous challenge to health care systems throughout the world. Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. To explore possible associations of vitamin...

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Hauptverfasser: Radujković, Aleksandar (VerfasserIn) , Wenz, Theresa (VerfasserIn) , Tiwari-Heckler, Shilpa (VerfasserIn) , Dreher, Saida (VerfasserIn) , Boxberger, Monica (VerfasserIn) , Merle, Uta (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 10 September 2020
In: Nutrients
Year: 2020, Jahrgang: 12, Heft: 9
ISSN:2072-6643
DOI:10.3390/nu12092757
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/nu12092757
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6643/12/9/2757
Volltext
Verfasserangaben:Aleksandar Radujkovic, Theresa Hippchen, Shilpa Tiwari-Heckler, Saida Dreher, Monica Boxberger and Uta Merle

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520 |a Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses an enormous challenge to health care systems throughout the world. Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. To explore possible associations of vitamin D (VitD) status with disease severity and survival, we studied 185 patients diagnosed with coronavirus disease 2019 (COVID-19) and treated at our center. VitD status at first presentation was assessed retrospectively using accredited laboratory methods. VitD deficiency was defined as serum total 25-hydroxyvitamin D level < 12 ng/mL (<30 nM). Primary endpoint was severe course of disease (i.e., need for invasive mechanical ventilation and/or death, IMV/D). Within a median observation period of 66 days (range 2&ndash;92), 23 patients required IMV. A total of 28 patients had IMV/D, including 16 deaths. Ninety-three (50%) patients required hospitalization (inpatient subgroup). A total of 41 (22%) patients were VitD deficient. When adjusted for age, gender, and comorbidities, VitD deficiency was associated with higher risk of IMV/D and death (HR 6.12, 95% CI 2.79&ndash;13.42, p < 0.001 and HR 14.73, 95% CI 4.16&ndash;52.19, p < 0.001, respectively). Similar correlations were observed in the inpatient subgroup. Our study demonstrates an association between VitD deficiency and severity/mortality of COVID-19, highlighting the need for interventional studies on VitD supplementation in SARS-CoV-2 infected individuals. 
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