Identification of interleukin1β as an amplifier of interferon alpha-induced antiviral responses
The induction of an interferon-mediated response is the first line of defense against pathogens such as viruses. Yet, the dynamics and extent of interferon alpha (IFNα)-induced antiviral genes vary remarkably and comprise three expression clusters: early, intermediate and late. By mathematical model...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 1, 2020
|
| In: |
PLoS pathogens
Year: 2020, Jahrgang: 16, Heft: 10 |
| ISSN: | 1553-7374 |
| DOI: | 10.1371/journal.ppat.1008461 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.ppat.1008461 Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008461 
|
| Verfasserangaben: | Katharina Robichon, Tim Maiwald, Marcel Schilling, Annette Schneider, Joschka Willemsen, Florian Salopiata, Melissa Teusel, Clemens Kreutz, Christian Ehlting, Jun Huang, Sajib Chakraborty, Xiaoyun Huang, Georg Damm, Daniel Seehofer, Philipp A. Lang, Johannes G. Bode, Marco Binder, Ralf Bartenschlager, Jens Timmer, Ursula Klingmüller |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1738573249 | ||
| 003 | DE-627 | ||
| 005 | 20241228000909.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201112s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.ppat.1008461 |2 doi | |
| 035 | |a (DE-627)1738573249 | ||
| 035 | |a (DE-599)KXP1738573249 | ||
| 035 | |a (OCoLC)1341376607 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Robichon, Katharina |e VerfasserIn |0 (DE-588)1081630612 |0 (DE-627)846373327 |0 (DE-576)454535791 |4 aut | |
| 245 | 1 | 0 | |a Identification of interleukin1β as an amplifier of interferon alpha-induced antiviral responses |c Katharina Robichon, Tim Maiwald, Marcel Schilling, Annette Schneider, Joschka Willemsen, Florian Salopiata, Melissa Teusel, Clemens Kreutz, Christian Ehlting, Jun Huang, Sajib Chakraborty, Xiaoyun Huang, Georg Damm, Daniel Seehofer, Philipp A. Lang, Johannes G. Bode, Marco Binder, Ralf Bartenschlager, Jens Timmer, Ursula Klingmüller |
| 246 | 3 | 3 | |a Identification of interleukin1beta as an amplifier of interferon alpha-induced antiviral responses |
| 264 | 1 | |c October 1, 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.11.2020 | ||
| 520 | |a The induction of an interferon-mediated response is the first line of defense against pathogens such as viruses. Yet, the dynamics and extent of interferon alpha (IFNα)-induced antiviral genes vary remarkably and comprise three expression clusters: early, intermediate and late. By mathematical modeling based on time-resolved quantitative data, we identified mRNA stability as well as a negative regulatory loop as key mechanisms endogenously controlling the expression dynamics of IFNα-induced antiviral genes in hepatocytes. Guided by the mathematical model, we uncovered that this regulatory loop is mediated by the transcription factor IRF2 and showed that knock-down of IRF2 results in enhanced expression of early, intermediate and late IFNα-induced antiviral genes. Co-stimulation experiments with different pro-inflammatory cytokines revealed that this amplified expression dynamics of the early, intermediate and late IFNα-induced antiviral genes can also be achieved by co-application of IFNα and interleukin1 beta (IL1β). Consistently, we found that IL1β enhances IFNα-mediated repression of viral replication. Conversely, we observed that in IL1β receptor knock-out mice replication of viruses sensitive to IFNα is increased. Thus, IL1β is capable to potentiate IFNα-induced antiviral responses and could be exploited to improve antiviral therapies. | ||
| 650 | 4 | |a Antiviral therapy | |
| 650 | 4 | |a Gene expression | |
| 650 | 4 | |a Gene regulation | |
| 650 | 4 | |a Hepatocytes | |
| 650 | 4 | |a Messenger RNA | |
| 650 | 4 | |a Phosphorylation | |
| 650 | 4 | |a Small interfering RNA | |
| 650 | 4 | |a Viral gene expression | |
| 700 | 1 | |8 1\p |a Maiwald, Tim |e VerfasserIn |0 (DE-588)1021168173 |0 (DE-627)691487782 |0 (DE-576)362662118 |4 aut | |
| 700 | 1 | |a Schilling, Marcel |d 1977- |e VerfasserIn |0 (DE-588)13305120X |0 (DE-627)533308321 |0 (DE-576)265224136 |4 aut | |
| 700 | 1 | |a Kopp-Schneider, Annette |e VerfasserIn |0 (DE-588)1119160545 |0 (DE-627)872460444 |0 (DE-576)178153206 |4 aut | |
| 700 | 1 | |a Willemsen, Joschka |e VerfasserIn |0 (DE-588)1071737562 |0 (DE-627)826300111 |0 (DE-576)433284013 |4 aut | |
| 700 | 1 | |a Schwörer, Florian |e VerfasserIn |0 (DE-588)1139307320 |0 (DE-627)897060210 |0 (DE-576)493230823 |4 aut | |
| 700 | 1 | |a Teusel, Melissa |e VerfasserIn |4 aut | |
| 700 | 1 | |8 2\p |a Kreutz, Clemens |e VerfasserIn |0 (DE-588)1112633642 |0 (DE-627)866704442 |0 (DE-576)476701201 |4 aut | |
| 700 | 1 | |8 3\p |a Ehlting, Christian |d 1975- |e VerfasserIn |0 (DE-588)13217295X |0 (DE-627)519019059 |0 (DE-576)256726817 |4 aut | |
| 700 | 1 | |a Huang, Jun |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chakraborty, Sajib |e VerfasserIn |0 (DE-588)1123675465 |0 (DE-627)877356955 |0 (DE-576)481891501 |4 aut | |
| 700 | 1 | |a Huang, Xiaoyun |e VerfasserIn |0 (DE-588)1113019166 |0 (DE-627)867694602 |0 (DE-576)476814758 |4 aut | |
| 700 | 1 | |a Damm, Georg |e VerfasserIn |4 aut | |
| 700 | 1 | |8 4\p |a Seehofer, Daniel |d 1970- |e VerfasserIn |0 (DE-588)123126835 |0 (DE-627)082362785 |0 (DE-576)293567751 |4 aut | |
| 700 | 1 | |8 5\p |a Lang, Philipp A. |d 1980- |e VerfasserIn |0 (DE-588)133631478 |0 (DE-627)550281665 |0 (DE-576)266901522 |4 aut | |
| 700 | 1 | |8 6\p |a Bode, Johannes G. |d 1967- |e VerfasserIn |0 (DE-588)115533761 |0 (DE-627)691385750 |0 (DE-576)17730281X |4 aut | |
| 700 | 1 | |a Binder, Marco |e VerfasserIn |0 (DE-588)13571379X |0 (DE-627)69371171X |0 (DE-576)300603509 |4 aut | |
| 700 | 1 | |a Bartenschlager, Ralf |d 1958- |e VerfasserIn |0 (DE-588)1058097989 |0 (DE-627)796390509 |0 (DE-576)168706067 |4 aut | |
| 700 | 1 | |8 7\p |a Timmer, Jens |d 1964- |e VerfasserIn |0 (DE-588)114318549 |0 (DE-627)562988742 |0 (DE-576)289793092 |4 aut | |
| 700 | 1 | |a Klingmüller, Ursula |d 1964- |e VerfasserIn |0 (DE-588)1098573455 |0 (DE-627)857742876 |0 (DE-576)46917014X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a Public Library of Science |t PLoS pathogens |d Lawrence, Kan. : PLoS, 2005 |g 16(2020,10) Artikel-Nummer e1008461, 33 Seiten |h Online-Ressource |w (DE-627)501074422 |w (DE-600)2205412-1 |w (DE-576)273890530 |x 1553-7374 |7 nnas |
| 773 | 1 | 8 | |g volume:16 |g year:2020 |g number:10 |a Identification of interleukin1β as an amplifier of interferon alpha-induced antiviral responses |
| 856 | 4 | 0 | |u https://doi.org/10.1371/journal.ppat.1008461 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008461 |x Verlag |z lizenzpflichtig |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 3\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 4\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 5\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 6\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 7\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20201112 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1098573455 |a Klingmüller, Ursula |m 1098573455:Klingmüller, Ursula |d 140000 |e 140000PK1098573455 |k 0/140000/ |p 20 |y j | ||
| 998 | |g 1058097989 |a Bartenschlager, Ralf |m 1058097989:Bartenschlager, Ralf |d 910000 |d 911700 |d 50000 |e 910000PB1058097989 |e 911700PB1058097989 |e 50000PB1058097989 |k 0/910000/ |k 1/910000/911700/ |k 0/50000/ |p 18 | ||
| 998 | |g 13571379X |a Binder, Marco |m 13571379X:Binder, Marco |d 140000 |d 50000 |e 140000PB13571379X |e 50000PB13571379X |k 0/140000/ |k 0/50000/ |p 17 | ||
| 998 | |g 1119160545 |a Kopp-Schneider, Annette |m 1119160545:Kopp-Schneider, Annette |d 50000 |e 50000PK1119160545 |k 0/50000/ |p 4 | ||
| 998 | |g 13305120X |a Schilling, Marcel |m 13305120X:Schilling, Marcel |d 50000 |e 50000PS13305120X |k 0/50000/ |p 3 | ||
| 999 | |a KXP-PPN1738573249 |e 3801035425 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"note":["Gesehen am 12.11.2020"],"recId":"1738573249","relHost":[{"language":["eng"],"pubHistory":["1.2005,Sept. -"],"part":{"year":"2020","text":"16(2020,10) Artikel-Nummer e1008461, 33 Seiten","issue":"10","volume":"16"},"id":{"eki":["501074422"],"issn":["1553-7374"],"zdb":["2205412-1"]},"origin":[{"dateIssuedDisp":"2005-","publisher":"PLoS","dateIssuedKey":"2005","publisherPlace":"Lawrence, Kan."}],"name":{"displayForm":["Public Library of Science"]},"disp":"Public Library of SciencePLoS pathogens","title":[{"title_sort":"PLoS pathogens","title":"PLoS pathogens"}],"physDesc":[{"extent":"Online-Ressource"}],"recId":"501074422","corporate":[{"role":"aut","display":"Public Library of Science"}],"note":["Gesehen am 20.11.2020"],"titleAlt":[{"title":"Pathogens"}],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"title":[{"title_sort":"Identification of interleukin1β as an amplifier of interferon alpha-induced antiviral responses","title":"Identification of interleukin1β as an amplifier of interferon alpha-induced antiviral responses"}],"name":{"displayForm":["Katharina Robichon, Tim Maiwald, Marcel Schilling, Annette Schneider, Joschka Willemsen, Florian Salopiata, Melissa Teusel, Clemens Kreutz, Christian Ehlting, Jun Huang, Sajib Chakraborty, Xiaoyun Huang, Georg Damm, Daniel Seehofer, Philipp A. Lang, Johannes G. Bode, Marco Binder, Ralf Bartenschlager, Jens Timmer, Ursula Klingmüller"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"given":"Katharina","display":"Robichon, Katharina","role":"aut","family":"Robichon"},{"given":"Tim","family":"Maiwald","role":"aut","display":"Maiwald, Tim"},{"given":"Marcel","role":"aut","display":"Schilling, Marcel","family":"Schilling"},{"family":"Kopp-Schneider","display":"Kopp-Schneider, Annette","role":"aut","given":"Annette"},{"given":"Joschka","family":"Willemsen","role":"aut","display":"Willemsen, Joschka"},{"given":"Florian","role":"aut","display":"Schwörer, Florian","family":"Schwörer"},{"given":"Melissa","family":"Teusel","role":"aut","display":"Teusel, Melissa"},{"role":"aut","display":"Kreutz, Clemens","family":"Kreutz","given":"Clemens"},{"display":"Ehlting, Christian","role":"aut","family":"Ehlting","given":"Christian"},{"given":"Jun","role":"aut","display":"Huang, Jun","family":"Huang"},{"given":"Sajib","family":"Chakraborty","role":"aut","display":"Chakraborty, Sajib"},{"display":"Huang, Xiaoyun","role":"aut","family":"Huang","given":"Xiaoyun"},{"given":"Georg","family":"Damm","display":"Damm, Georg","role":"aut"},{"role":"aut","display":"Seehofer, Daniel","family":"Seehofer","given":"Daniel"},{"given":"Philipp A.","display":"Lang, Philipp A.","role":"aut","family":"Lang"},{"family":"Bode","display":"Bode, Johannes G.","role":"aut","given":"Johannes G."},{"family":"Binder","display":"Binder, Marco","role":"aut","given":"Marco"},{"given":"Ralf","display":"Bartenschlager, Ralf","role":"aut","family":"Bartenschlager"},{"role":"aut","display":"Timmer, Jens","family":"Timmer","given":"Jens"},{"given":"Ursula","display":"Klingmüller, Ursula","role":"aut","family":"Klingmüller"}],"id":{"eki":["1738573249"],"doi":["10.1371/journal.ppat.1008461"]},"titleAlt":[{"title":"Identification of interleukin1beta as an amplifier of interferon alpha-induced antiviral responses"}],"origin":[{"dateIssuedDisp":"October 1, 2020","dateIssuedKey":"2020"}]} | ||
| SRT | |a ROBICHONKAIDENTIFICA1202 | ||