Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult mice
Aging is associated with the progressive decay of cognitive function. Hippocampus-dependent processes, such as the formation of spatial memory, are particularly vulnerable to aging. Currently, the molecular mechanisms responsible for age-dependent cognitive decline are largely unknown. Here, we inve...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 July 2020
|
| In: |
Neurobiology of aging
Year: 2020, Jahrgang: 94, Pages: 281-286 |
| ISSN: | 1558-1497 |
| DOI: | 10.1016/j.neurobiolaging.2020.06.021 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neurobiolaging.2020.06.021 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0197458020302141 
|
| Verfasserangaben: | David V.C. Brito, Kubra Gulmez Karaca, Janina Kupke, Franziska Mudlaff, Benjamin Zeuch, Rui Gomes, Luísa V. Lopes, Ana M.M. Oliveira |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1738588505 | ||
| 003 | DE-627 | ||
| 005 | 20220819022957.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201112s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.neurobiolaging.2020.06.021 |2 doi | |
| 035 | |a (DE-627)1738588505 | ||
| 035 | |a (DE-599)KXP1738588505 | ||
| 035 | |a (OCoLC)1341376420 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Brito, David V. C. |d 1992- |e VerfasserIn |0 (DE-588)1201212650 |0 (DE-627)168468269X |4 aut | |
| 245 | 1 | 0 | |a Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult mice |c David V.C. Brito, Kubra Gulmez Karaca, Janina Kupke, Franziska Mudlaff, Benjamin Zeuch, Rui Gomes, Luísa V. Lopes, Ana M.M. Oliveira |
| 264 | 1 | |c 3 July 2020 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.11.2020 | ||
| 520 | |a Aging is associated with the progressive decay of cognitive function. Hippocampus-dependent processes, such as the formation of spatial memory, are particularly vulnerable to aging. Currently, the molecular mechanisms responsible for age-dependent cognitive decline are largely unknown. Here, we investigated the expression and function of the growth arrest DNA damage gamma (Gadd45γ) during aging and cognition. We report that Gadd45γ expression is increased in the hippocampus of aged humans and that Gadd45γ overexpression in the young adult mouse hippocampus compromises cognition. Moreover, Gadd45γ overexpression in hippocampal neurons disrupted cAMP response element-binding protein signaling and the expression of well-established activity-regulated genes. This work shows that Gadd45γ expression is tightly controlled in the hippocampus and its disruption may be a mechanism contributing to age-related cognitive impairments observed in humans. | ||
| 650 | 4 | |a Activity-regulated gene expression | |
| 650 | 4 | |a Age-related cognitive deficits | |
| 650 | 4 | |a CREB | |
| 650 | 4 | |a Gadd45γ | |
| 650 | 4 | |a Object location memory | |
| 700 | 1 | |a Gülmez Karaca, Kübra |d 1990- |e VerfasserIn |0 (DE-588)1199273422 |0 (DE-627)1681559021 |4 aut | |
| 700 | 1 | |a Kupke, Janina |d 1993- |e VerfasserIn |0 (DE-588)1157037186 |0 (DE-627)1020034890 |0 (DE-576)502583061 |4 aut | |
| 700 | 1 | |a Mudlaff, Franziska |e VerfasserIn |0 (DE-588)1221316907 |0 (DE-627)1738590410 |4 aut | |
| 700 | 1 | |a Zeuch, Benjamin |e VerfasserIn |0 (DE-588)1199273082 |0 (DE-627)1681558688 |4 aut | |
| 700 | 1 | |a Gomes, Rui |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lopes, Luísa V. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Oliveira, Ana |d 1979- |e VerfasserIn |0 (DE-588)1080530428 |0 (DE-627)844772526 |0 (DE-576)453595707 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neurobiology of aging |d Amsterdam [u.a.] : Elsevier Science, 1980 |g 94(2020), Seite 281-286 |h Online-Ressource |w (DE-627)306588552 |w (DE-600)1498414-3 |w (DE-576)081953062 |x 1558-1497 |7 nnas |a Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult mice |
| 773 | 1 | 8 | |g volume:94 |g year:2020 |g pages:281-286 |g extent:6 |a Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult mice |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.neurobiolaging.2020.06.021 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0197458020302141 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201112 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1080530428 |a Oliveira, Ana |m 1080530428:Oliveira, Ana |p 5 | ||
| 998 | |g 1221316907 |a Mudlaff, Franziska |m 1221316907:Mudlaff, Franziska |d 700000 |d 712000 |d 712100 |e 700000PM1221316907 |e 712000PM1221316907 |e 712100PM1221316907 |k 0/700000/ |k 1/700000/712000/ |k 2/700000/712000/712100/ |p 4 | ||
| 998 | |g 1157037186 |a Kupke, Janina |m 1157037186:Kupke, Janina |d 700000 |d 712000 |d 712100 |e 700000PK1157037186 |e 712000PK1157037186 |e 712100PK1157037186 |k 0/700000/ |k 1/700000/712000/ |k 2/700000/712000/712100/ |p 3 | ||
| 998 | |g 1199273422 |a Gülmez Karaca, Kübra |m 1199273422:Gülmez Karaca, Kübra |p 2 | ||
| 998 | |g 1201212650 |a Brito, David V. C. |m 1201212650:Brito, David V. C. |d 700000 |d 712000 |d 712100 |e 700000PB1201212650 |e 712000PB1201212650 |e 712100PB1201212650 |k 0/700000/ |k 1/700000/712000/ |k 2/700000/712000/712100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1738588505 |e 3801081133 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult mice","title_sort":"Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult mice"}],"language":["eng"],"name":{"displayForm":["David V.C. Brito, Kubra Gulmez Karaca, Janina Kupke, Franziska Mudlaff, Benjamin Zeuch, Rui Gomes, Luísa V. Lopes, Ana M.M. Oliveira"]},"person":[{"family":"Brito","given":"David V. C.","role":"aut","display":"Brito, David V. C."},{"display":"Gülmez Karaca, Kübra","given":"Kübra","role":"aut","family":"Gülmez Karaca"},{"family":"Kupke","display":"Kupke, Janina","given":"Janina","role":"aut"},{"family":"Mudlaff","role":"aut","given":"Franziska","display":"Mudlaff, Franziska"},{"role":"aut","given":"Benjamin","display":"Zeuch, Benjamin","family":"Zeuch"},{"role":"aut","given":"Rui","display":"Gomes, Rui","family":"Gomes"},{"display":"Lopes, Luísa V.","given":"Luísa V.","role":"aut","family":"Lopes"},{"given":"Ana","role":"aut","display":"Oliveira, Ana","family":"Oliveira"}],"origin":[{"dateIssuedDisp":"3 July 2020","dateIssuedKey":"2020"}],"recId":"1738588505","type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"6 S."}],"id":{"eki":["1738588505"],"doi":["10.1016/j.neurobiolaging.2020.06.021"]},"relHost":[{"title":[{"title":"Neurobiology of aging","title_sort":"Neurobiology of aging"}],"language":["eng"],"part":{"extent":"6","pages":"281-286","volume":"94","text":"94(2020), Seite 281-286","year":"2020"},"pubHistory":["1.1980 -"],"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1980","dateIssuedDisp":"1980-","publisher":"Elsevier Science"}],"recId":"306588552","physDesc":[{"extent":"Online-Ressource"}],"disp":"Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult miceNeurobiology of aging","id":{"zdb":["1498414-3"],"issn":["1558-1497"],"eki":["306588552"]},"note":["Gesehen am 14.02.20","Ungezählte Beil.: Supplement"]}],"note":["Gesehen am 12.11.2020"]} | ||
| SRT | |a BRITODAVIDMODELINGHU3202 | ||