Better prognosis of gastric cancer patients with high levels of tumor infiltrating lymphocytes is counteracted by PD-1 expression
The prognostic potential of anti-tumor immune responses is becoming increasingly important in adenocarcinoma of the gastroesophageal junction and stomach (AGE/S) especially regarding the use of immune checkpoint inhibitors. This study analyzes for the first time the prognostic impact of tumor-infilt...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
20 September 2020
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| In: |
OncoImmunology
Year: 2020, Volume: 9 |
| ISSN: | 2162-402X |
| DOI: | 10.1080/2162402X.2020.1824632 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/2162402X.2020.1824632
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| Author Notes: | M. Pötzsch, E. Berg, M. Hummel, U. Stein, M. von Winterfeld, K. Jöhrens, B. Rau, S. Daum, snd C. Treese |
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| 520 | |a The prognostic potential of anti-tumor immune responses is becoming increasingly important in adenocarcinoma of the gastroesophageal junction and stomach (AGE/S) especially regarding the use of immune checkpoint inhibitors. This study analyzes for the first time the prognostic impact of tumor-infiltrating lymphocytes (TILs) and checkpoint inhibitors in a large Caucasian cohort in patients with AGE/S. We screened tissue samples from 438 therapy-naïve patients with AGE/S undergoing surgery between 1992 and 2005, examined in a tissue microarray (TMA) and stained against human CD3, CD4, CD8, PD-1, and PD-L1. Out of 438 tissue samples, 210 were eligible for multivariate analysis. This revealed that high infiltration with CD3+, CD4+, or CD8+ TILs was associated with an increased overall survival in AGE/S patients, which could only be confirmed in multivariate analysis for CD3 (HR: 0.326; p = .023). Independent improved survival was limited to gastric cancer patients and to early tumor stages as long as TILs did not express PD-1 (HR: 1.522; p = .021). Subgroup analyses indicate that TIL-dependent anti-tumor immune response is only effective in gastric cancer patients in early stages of disease in PD-1 negative TILs. Combined analysis of PD-1 and CD3 could serve as a prognostic marker for the clinical outcome of gastric cancer patients and could also be of interest for immunotherapy. | ||
| 650 | 4 | |a biomarker | |
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| 700 | 1 | |a Hummel, M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stein, U. |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Daum, S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Treese, C. |e VerfasserIn |4 aut | |
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