Buchumschlag

Deficiency in Aim2 affects viability and calcification of vascular smooth muscle cells from murine aortas and angiotensin-II induced aortic aneurysms

Phenotypic transformation of vascular smooth muscle cells is a key element in vascular remodeling and aortic aneurysm growth. Previously, deletion of several inflammasome components decreased formation of aortic aneurysm (AA) in the Angiotensin II (AngII) -induced mouse model. We hypothesized that t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Wortmann, Markus (VerfasserIn) , Hakimi, Maani (VerfasserIn) , Böckler, Dittmar (VerfasserIn) , Dihlmann, Susanne (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 15 September 2020
In: Molecular medicine
Year: 2020, Jahrgang: 26, Heft: 1
ISSN:1528-3658
DOI:10.1186/s10020-020-00212-z
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s10020-020-00212-z
Volltext
Verfasserangaben:Markus Wortmann, Muhammad Arshad, Maani Hakimi, Dittmar Böckler and Susanne Dihlmann
Beschreibung
Zusammenfassung:Phenotypic transformation of vascular smooth muscle cells is a key element in vascular remodeling and aortic aneurysm growth. Previously, deletion of several inflammasome components decreased formation of aortic aneurysm (AA) in the Angiotensin II (AngII) -induced mouse model. We hypothesized that the inflammasome sensor Absent in melanoma 2 (Aim2) might affect the phenotype of vascular smooth muscle cells (VSMC), thereby reducing AA formation.
Beschreibung:Gesehen am 13.11.2020
Beschreibung:Online Resource
ISSN:1528-3658
DOI:10.1186/s10020-020-00212-z

Ähnliche Einträge