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Transcriptional regulator PRDM12 is essential for human pain perception

Geoffrey Woods, Jan Senderek and colleagues show that biallelic mutations in PRDM12 cause congenital insensitivity to pain. They further show that PRDM12 is expressed in nociceptors and their progenitors and participates in sensory neuron development in Xenopus.

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Main Authors: Chen, Ya-Chun (Author) , Auer-Grumbach, Michaela (Author) , Matsukawa, Shinya (Author) , Zitzelsberger, Manuela (Author) , Themistocleous, Andreas C. (Author) , Strom, Tim M. (Author) , Samara, Chrysanthi (Author) , Moore, Adrian W. (Author) , Cho, Lily Ting-Yin (Author) , Young, Gareth T. (Author) , Weiss, Caecilia (Author) , Schabhüttl, Maria (Author) , Stucka, Rolf (Author) , Schmid, Annina B. (Author) , Parman, Yesim (Author) , Graul-Neumann, Luitgard (Author) , Heinritz, Wolfram (Author) , Passarge, Eberhard (Author) , Watson, Rosemarie M. (Author) , Hertz, Jens Michael (Author) , Moog, Ute (Author) , Baumgartner, Manuela (Author) , Valente, Enza Maria (Author) , Pereira, Diego (Author) , Restrepo, Carlos M. (Author) , Katona, Istvan (Author) , Dusl, Marina (Author) , Stendel, Claudia (Author) , Wieland, Thomas (Author) , Stafford, Fay (Author) , Reimann, Frank (Author) , von Au, Katja (Author) , Finke, Christian (Author) , Willems, Patrick J. (Author) , Nahorski, Michael S. (Author) , Shaikh, Samiha S. (Author) , Carvalho, Ofélia P. (Author) , Nicholas, Adeline K. (Author) , Karbani, Gulshan (Author) , McAleer, Maeve A. (Author) , Cilio, Maria Roberta (Author) , McHugh, John C. (Author) , Murphy, Sinead M. (Author) , Irvine, Alan D. (Author) , Jensen, Uffe Birk (Author) , Windhager, Reinhard (Author) , Weis, Joachim (Author) , Bergmann, Carsten (Author) , Rautenstrauss, Bernd (Author) , Baets, Jonathan (Author) , De Jonghe, Peter (Author) , Reilly, Mary M. (Author) , Kropatsch, Regina (Author) , Kurth, Ingo (Author) , Chrast, Roman (Author) , Michiue, Tatsuo (Author) , Bennett, David L. H. (Author) , Woods, C. Geoffrey (Author) , Senderek, Jan (Author)
Format: Article (Journal)
Language:English
Published: 25 May 2015
In: Nature genetics
Year: 2015, Volume: 47, Issue: 7, Pages: 803-808
ISSN:1546-1718
DOI:10.1038/ng.3308
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ng.3308
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ng.3308
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Author Notes:Ya-Chun Chen, Michaela Auer-Grumbach, Shinya Matsukawa, Manuela Zitzelsberger, Andreas C. Themistocleous, Tim M. Strom, Chrysanthi Samara, Adrian W. Moore, Lily Ting-Yin Cho, Gareth T. Young, Caecilia Weiss, Maria Schabhüttl, Rolf Stucka, Annina B. Schmid, Yesim Parman, Luitgard Graul-Neumann, Wolfram Heinritz, Eberhard Passarge, Rosemarie M. Watson, Jens Michael Hertz, Ute Moog, Manuela Baumgartner, Enza Maria Valente, Diego Pereira, Carlos M. Restrepo, Istvan Katona, Marina Dusl, Claudia Stendel, Thomas Wieland, Fay Stafford, Frank Reimann, Katja von Au, Christian Finke, Patrick J. Willems, Michael S. Nahorski, Samiha S. Shaikh, Ofélia P. Carvalho, Adeline K. Nicholas, Gulshan Karbani, Maeve A. McAleer, Maria Roberta Cilio, John C. McHugh, Sinead M. Murphy, Alan D. Irvine, Uffe Birk Jensen, Reinhard Windhager, Joachim Weis, Carsten Bergmann, Bernd Rautenstrauss, Jonathan Baets, Peter De Jonghe, Mary M. Reilly, Regina Kropatsch, Ingo Kurth, Roman Chrast, Tatsuo Michiue, David L. H. Bennett, C. Geoffrey Woods & Jan Senderek
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Summary:Geoffrey Woods, Jan Senderek and colleagues show that biallelic mutations in PRDM12 cause congenital insensitivity to pain. They further show that PRDM12 is expressed in nociceptors and their progenitors and participates in sensory neuron development in Xenopus.
Item Description:Gesehen am 16.11.2020
Physical Description:Online Resource
ISSN:1546-1718
DOI:10.1038/ng.3308

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