ER stress-induced secretion of proteins and their extracellular functions in the heart
Endoplasmic reticulum (ER) stress is a result of conditions that imbalance protein homeostasis or proteostasis at the ER, for example ischemia, and is a common event in various human pathologies, including the diseased heart. Cardiac integrity and function depend on the active secretion of mature pr...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 September 2020
|
| In: |
Cells
Year: 2020, Jahrgang: 9, Heft: 9 |
| ISSN: | 2073-4409 |
| DOI: | 10.3390/cells9092066 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/cells9092066 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2073-4409/9/9/2066 
|
| Verfasserangaben: | Bianca A. Meyer and Shirin Doroudgar |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1738738698 | ||
| 003 | DE-627 | ||
| 005 | 20230426122303.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201116s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/cells9092066 |2 doi | |
| 035 | |a (DE-627)1738738698 | ||
| 035 | |a (DE-599)KXP1738738698 | ||
| 035 | |a (OCoLC)1341377644 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Meyer, Bianca A. |e VerfasserIn |0 (DE-588)1221535129 |0 (DE-627)1738740471 |4 aut | |
| 245 | 1 | 0 | |a ER stress-induced secretion of proteins and their extracellular functions in the heart |c Bianca A. Meyer and Shirin Doroudgar |
| 264 | 1 | |c 10 September 2020 | |
| 300 | |a 17 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 16.11.2020 | ||
| 520 | |a Endoplasmic reticulum (ER) stress is a result of conditions that imbalance protein homeostasis or proteostasis at the ER, for example ischemia, and is a common event in various human pathologies, including the diseased heart. Cardiac integrity and function depend on the active secretion of mature proteins from a variety of cell types in the heart, a process that requires an intact ER environment for efficient protein folding and trafficking to the secretory pathway. As a consequence of ER stress, most protein secretion by the ER secretory pathway is decreased. Strikingly, there is a select group of proteins that are secreted in greater quantities during ER stress. ER stress resulting from the dysregulation of ER Ca2+ levels, for instance, stimulates the secretion of Ca2+-binding ER chaperones, especially GRP78, GRP94, calreticulin, and mesencephalic astrocyte-derived neurotrophic factor (MANF), which play a multitude of roles outside the cell, strongly depending on the cell type and tissue. Here we review current insights in ER stress-induced secretion of proteins, particularly from the heart, and highlight the extracellular functions of these proteins, ranging from the augmentation of cardiac cell viability to the modulation of pro- and anti-apoptotic, oncogenic, and immune-stimulatory cell signaling, cell invasion, extracellular proteostasis, and more. Many of the roles of ER stress-induced protein secretion remain to be explored in the heart. This article is part of a special issue entitled “The Role of Proteostasis Derailment in Cardiac Diseases.” | ||
| 650 | 4 | |a cardiac myocytes | |
| 650 | 4 | |a cardiokines | |
| 650 | 4 | |a cell signaling | |
| 650 | 4 | |a ER stress | |
| 650 | 4 | |a protein secretion | |
| 650 | 4 | |a proteostasis | |
| 650 | 4 | |a secreted ER chaperones | |
| 650 | 4 | |a unfolded protein response (UPR) | |
| 700 | 1 | |a Doroudgar, Shirin |e VerfasserIn |0 (DE-588)1139390260 |0 (DE-627)897138023 |0 (DE-576)493250972 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cells |d Basel : MDPI, 2012 |g 9(2020,9) Artikel-Nummer 2066, 17 Seiten |h Online-Ressource |w (DE-627)718622081 |w (DE-600)2661518-6 |w (DE-576)365412112 |x 2073-4409 |7 nnas |a ER stress-induced secretion of proteins and their extracellular functions in the heart |
| 773 | 1 | 8 | |g volume:9 |g year:2020 |g number:9 |g extent:17 |a ER stress-induced secretion of proteins and their extracellular functions in the heart |
| 856 | 4 | 0 | |u https://doi.org/10.3390/cells9092066 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2073-4409/9/9/2066 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201116 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1139390260 |a Doroudgar, Shirin |m 1139390260:Doroudgar, Shirin |d 910000 |d 910100 |e 910000PD1139390260 |e 910100PD1139390260 |k 0/910000/ |k 1/910000/910100/ |p 2 |y j | ||
| 999 | |a KXP-PPN1738738698 |e 3804270425 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"title":[{"title_sort":"Cells","title":"Cells","subtitle":"open access journal"}],"pubHistory":["1.2012 -"],"part":{"issue":"9","year":"2020","extent":"17","volume":"9","text":"9(2020,9) Artikel-Nummer 2066, 17 Seiten"},"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"ER stress-induced secretion of proteins and their extracellular functions in the heartCells","note":["Gesehen am 09.05.12"],"language":["eng"],"recId":"718622081","origin":[{"dateIssuedDisp":"2012-","dateIssuedKey":"2012","publisher":"MDPI","publisherPlace":"Basel"}],"id":{"eki":["718622081"],"zdb":["2661518-6"],"issn":["2073-4409"]},"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"17 S."}],"id":{"eki":["1738738698"],"doi":["10.3390/cells9092066"]},"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"10 September 2020"}],"name":{"displayForm":["Bianca A. Meyer and Shirin Doroudgar"]},"language":["eng"],"recId":"1738738698","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 16.11.2020"],"title":[{"title_sort":"ER stress-induced secretion of proteins and their extracellular functions in the heart","title":"ER stress-induced secretion of proteins and their extracellular functions in the heart"}],"person":[{"role":"aut","display":"Meyer, Bianca A.","roleDisplay":"VerfasserIn","given":"Bianca A.","family":"Meyer"},{"given":"Shirin","family":"Doroudgar","role":"aut","display":"Doroudgar, Shirin","roleDisplay":"VerfasserIn"}]} | ||
| SRT | |a MEYERBIANCERSTRESSIN1020 | ||