Overcoming immunosuppression as a new immunotherapeutic approach against pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of malignancy. Via a broad stimulation of the immune system, PDAC activates both antitumor immune responses and immunosuppressive mechanisms. We propose that new immunotherapeutic strategies for the management of PDAC should be de...
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| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 Jul 2013
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| In: |
OncoImmunology
Year: 2013, Volume: 2, Issue: 9 |
| ISSN: | 2162-402X |
| DOI: | 10.4161/onci.25736 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4161/onci.25736 |
| Author Notes: | Alexandr V Bazhin, Jagadeesh Bayry, Viktor Umansky, Jens Werner, and Svetlana Karakhanova |
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| 520 | |a Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of malignancy. Via a broad stimulation of the immune system, PDAC activates both antitumor immune responses and immunosuppressive mechanisms. We propose that new immunotherapeutic strategies for the management of PDAC should be designed to specifically neutralize the immunosuppressive tumor microenvironment. | ||
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