No DDRama at chromosome ends: TRF2 takes centre stage
Telomeres are nucleoprotein structures capping the natural termini of eukaryotic linear chromosomes. Telomeres possess an inherent ability to circumvent the activation of a full-blown DNA damage response (DDR), and hence fusion reactions, by limiting inappropriate double-strand break (DSB) repair an...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 April 2015
|
| In: |
Trends in biochemical sciences
Year: 2015, Jahrgang: 40, Heft: 5, Pages: 275-285 |
| ISSN: | 1362-4326 |
| DOI: | 10.1016/j.tibs.2015.03.003 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tibs.2015.03.003 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0968000415000419 
|
| Verfasserangaben: | Sascha Feuerhahn, Liuh-yow Chen, Brian Luke, and Antonio Porro |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1738892271 | ||
| 003 | DE-627 | ||
| 005 | 20220819024939.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201117s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.tibs.2015.03.003 |2 doi | |
| 035 | |a (DE-627)1738892271 | ||
| 035 | |a (DE-599)KXP1738892271 | ||
| 035 | |a (OCoLC)1341376506 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Feuerhahn, Sascha |e VerfasserIn |0 (DE-588)1221616838 |0 (DE-627)1738890015 |4 aut | |
| 245 | 1 | 0 | |a No DDRama at chromosome ends |b TRF2 takes centre stage |c Sascha Feuerhahn, Liuh-yow Chen, Brian Luke, and Antonio Porro |
| 246 | 3 | 3 | |a No drama at chromosome ends |
| 264 | 1 | |c 3 April 2015 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 17.11.2020 | ||
| 520 | |a Telomeres are nucleoprotein structures capping the natural termini of eukaryotic linear chromosomes. Telomeres possess an inherent ability to circumvent the activation of a full-blown DNA damage response (DDR), and hence fusion reactions, by limiting inappropriate double-strand break (DSB) repair and processing activities at eukaryotic chromosome ends. A telomere-specific protein complex, termed shelterin, has a crucial function in safeguarding and securing telomere integrity. Within this complex, TRF2 has emerged as the key player, dictating different states of telomere protection during the replicative lifespan of a cell. How TRF2 prevents activation of DSB repair activities at functional telomeres has now been extensively investigated. In this review we aim at exploring the complex and multi-faceted mechanisms underlying the TRF2-mediated protection of eukaryotic chromosome ends. | ||
| 650 | 4 | |a chromatin | |
| 650 | 4 | |a DNA damage response | |
| 650 | 4 | |a t-loops | |
| 650 | 4 | |a telomeres | |
| 650 | 4 | |a TERRA | |
| 650 | 4 | |a TRF2 | |
| 700 | 1 | |a Chen, Liuh-yow |e VerfasserIn |4 aut | |
| 700 | 1 | |a Luke, Brian |e VerfasserIn |0 (DE-588)1043325530 |0 (DE-627)770445241 |0 (DE-576)178268100 |4 aut | |
| 700 | 1 | |a Porro, Antonio |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Trends in biochemical sciences |d Amsterdam [u.a.] : Elsevier Science, 1976 |g 40(2015), 5, Seite 275-285 |h Online-Ressource |w (DE-627)306593068 |w (DE-600)1498901-3 |w (DE-576)094113513 |x 1362-4326 |7 nnas |a No DDRama at chromosome ends TRF2 takes centre stage |
| 773 | 1 | 8 | |g volume:40 |g year:2015 |g number:5 |g pages:275-285 |g extent:11 |a No DDRama at chromosome ends TRF2 takes centre stage |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.tibs.2015.03.003 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0968000415000419 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201117 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1043325530 |a Luke, Brian |m 1043325530:Luke, Brian |d 700000 |d 706000 |e 700000PL1043325530 |e 706000PL1043325530 |k 0/700000/ |k 1/700000/706000/ |p 3 | ||
| 999 | |a KXP-PPN1738892271 |e 3805751451 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Sascha Feuerhahn, Liuh-yow Chen, Brian Luke, and Antonio Porro"]},"id":{"doi":["10.1016/j.tibs.2015.03.003"],"eki":["1738892271"]},"origin":[{"dateIssuedDisp":"3 April 2015","dateIssuedKey":"2015"}],"relHost":[{"title":[{"subtitle":"TIBS","title":"Trends in biochemical sciences","title_sort":"Trends in biochemical sciences"}],"part":{"pages":"275-285","issue":"5","year":"2015","extent":"11","volume":"40","text":"40(2015), 5, Seite 275-285"},"titleAlt":[{"title":"TIBS"}],"pubHistory":["1.1976 -"],"recId":"306593068","corporate":[{"roleDisplay":"Herausgebendes Organ","display":"International Union of Biochemistry and Molecular Biology","role":"isb"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"No DDRama at chromosome ends TRF2 takes centre stageTrends in biochemical sciences","note":["Gesehen am 28.05.20"],"id":{"zdb":["1498901-3"],"eki":["306593068"],"issn":["1362-4326"]},"origin":[{"dateIssuedDisp":"1976-","dateIssuedKey":"1976","publisher":"Elsevier Science","publisherPlace":"Amsterdam [u.a.]"}],"name":{"displayForm":["publ. by the International Union of Biochemistry and Molecular Biology and Elsevier Trends Journals"]},"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"11 S."}],"person":[{"given":"Sascha","family":"Feuerhahn","role":"aut","roleDisplay":"VerfasserIn","display":"Feuerhahn, Sascha"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Chen, Liuh-yow","given":"Liuh-yow","family":"Chen"},{"given":"Brian","family":"Luke","role":"aut","display":"Luke, Brian","roleDisplay":"VerfasserIn"},{"family":"Porro","given":"Antonio","roleDisplay":"VerfasserIn","display":"Porro, Antonio","role":"aut"}],"title":[{"title_sort":"No DDRama at chromosome ends","subtitle":"TRF2 takes centre stage","title":"No DDRama at chromosome ends"}],"language":["eng"],"recId":"1738892271","note":["Gesehen am 17.11.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"titleAlt":[{"title":"No drama at chromosome ends"}]} | ||
| SRT | |a FEUERHAHNSNODDRAMAAT3201 | ||