Nine-year follow-up of a case of Grzybowski type multiple keratoacanthomas and failure to demonstrate human papillomavirus
We describe a patient with a 9-year history of generalized eruptive keratoacanthoma (KA) of the Grzybowski type whose multiple skin lesions showed steady progression, resulting in a sclerotic, mask-like facial expression and ectropion. Eleven tumour biopsies representing lesions of different stages...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
04 October 2002
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| In: |
British journal of dermatology
Year: 2002, Volume: 147, Issue: 4, Pages: 793-796 |
| ISSN: | 1365-2133 |
| DOI: | https://doi.org/10.1046/j.1365-2133.2002.04925.x |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1046/j.1365-2133.2002.04925.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2133.2002.04925.x 
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| Author Notes: | N. Haas, D. Schadendorf, B.M. Henz and P.G. Fuchs |
MARC
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| 520 | |a We describe a patient with a 9-year history of generalized eruptive keratoacanthoma (KA) of the Grzybowski type whose multiple skin lesions showed steady progression, resulting in a sclerotic, mask-like facial expression and ectropion. Eleven tumour biopsies representing lesions of different stages and localizations (erupting and regressing KAs, biopsies from non-involved light-protected and light-exposed skin, dermatosclerosis and squamous cell carcinomas) were analysed for human papillomavirus (HPV) sequences using a polymerase chain reaction approach capable of detecting the majority of all presently known HPV genotypes. None of the biopsy specimens proved to be HPV-positive, although HPV was detected in weakly and heavily affected control specimens by the method applied. These findings suggest an HPV-independent aetiology of this rare type of multiple KA. | ||
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