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Treatment outcome in alcoholism: a comparison of self-report and the biological markers carbohydrate-deficient transferrin and γ-glutamyl transferase

The primary source for evaluating treatment outcome in alcoholism is usually verbal self-report. Because the validity of self-report is often doubted, more objective markers for treatment outcome are needed. In this study, we compared self-report data from 238 male alcohol-dependent patients partici...

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Hauptverfasser: Mundle, Götz (VerfasserIn) , Ackermann, Klaus (VerfasserIn) , Günthner, Arthur (VerfasserIn) , Munkes, Jörg (VerfasserIn) , Mann, Karl (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: June 1999
In: European addiction research
Year: 1999, Jahrgang: 5, Heft: 2, Pages: 91-96
ISSN:1421-9891
DOI:10.1159/000018972
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000018972
Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/18972
Volltext
Verfasserangaben:Götz Mundle, Klaus Ackermann, Arthur Günthner, Jörg Munkes, Karl Mann

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520 |a The primary source for evaluating treatment outcome in alcoholism is usually verbal self-report. Because the validity of self-report is often doubted, more objective markers for treatment outcome are needed. In this study, we compared self-report data from 238 male alcohol-dependent patients participating in a combined 6-week inpatient followed by a 1-year outpatient treatment program with the biological markers carbohydrate-deficient transferrin (CDT) and γ-glutamyl transferase (GGT). According to self-report, over 70% of the patients had a positive treatment outcome (57% abstinence, 16% intermediate relapse). These results are supported by the general reduction of CDT and GGT during the treatment period (p < 0.001). When we performed a cross-sectional analysis at 6 months during the outpatient program, there was a high consistency of self-report data with the biological markers (CDT 93%, GGT 91%, CDT/GGT 85%). Our results support the hypothesis that in abstinence- oriented treatment programs, self-reports are valid and can be used as the basis of measurement for treatment outcome. 
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