Cover Image

Long-term follow-up of children conditioned with Treosulfan: German and Austrian experience

We report the long-term follow-up of children transplanted with Treosulfan (TREO)-based conditioning in Germany and Austria. Nine centres reported a total of 109 transplantations. Patients were stratified according to the paediatric TRM risk score derived from the paediatric BMT registry (PRST) and...

Full description

Saved in:
Bibliographic Details
Main Authors: Beier, Rita (Author) , Schulz, A. (Author) , Hönig, M. (Author) , Eyrich, M. (Author) , Schlegel, P.-G. (Author) , Holter, W. (Author) , Stachel, K. D. (Author) , Ehlert, K. (Author) , Greil, Johann (Author) , Nürnberger, W. (Author) , Wößmann, W. (Author) , Bader, P. (Author) , Urban, C. (Author) , Müller, I. (Author) , Suttorp, M. (Author) , Sauer, M. (Author) , Gruhn, B. (Author) , Meisel, R. (Author) , Zimmermann, M. (Author) , Sykora, Karl-Walter (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: Bone marrow transplantation
Year: 2012, Volume: 48, Issue: 4, Pages: 491-501
ISSN:1476-5365
DOI:10.1038/bmt.2012.188
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/bmt.2012.188
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/bmt2012188
Get full text
Author Notes:R Beier, A Schulz, M Hönig, M Eyrich, P-G Schlegel, W Holter, KD Stachel, K Ehlert, J Greil, W Nürnberger, W Wößmann, P Bader, C Urban, I Müller, M Suttorp, M Sauer, B Gruhn, R Meisel, M Zimmermann and K-W Sykora

MARC

LEADER 00000caa a2200000 c 4500
001 1739144228
003 DE-627
005 20230428084843.0
007 cr uuu---uuuuu
008 201119r20132012xx |||||o 00| ||eng c
024 7 |a 10.1038/bmt.2012.188  |2 doi 
035 |a (DE-627)1739144228 
035 |a (DE-599)KXP1739144228 
035 |a (OCoLC)1341377923 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Beier, Rita  |d 1972-  |e VerfasserIn  |0 (DE-588)120531682  |0 (DE-627)696756609  |0 (DE-576)29226528X  |4 aut 
245 1 0 |a Long-term follow-up of children conditioned with Treosulfan  |b German and Austrian experience  |c R Beier, A Schulz, M Hönig, M Eyrich, P-G Schlegel, W Holter, KD Stachel, K Ehlert, J Greil, W Nürnberger, W Wößmann, P Bader, C Urban, I Müller, M Suttorp, M Sauer, B Gruhn, R Meisel, M Zimmermann and K-W Sykora 
264 1 |c 2013 
300 |a 11 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 19.11.2020 
500 |a First published: 22 October 2012 
520 |a We report the long-term follow-up of children transplanted with Treosulfan (TREO)-based conditioning in Germany and Austria. Nine centres reported a total of 109 transplantations. Patients were stratified according to the paediatric TRM risk score derived from the paediatric BMT registry (PRST) and compared with the historical transplant population of this registry. Underlying diseases were malignancies, immunodeficiencies, and haematologic and metabolic disorders. TREO total dose ranged from 21-42 g/m2. Additional conditioning drugs included fludarabine, thiotepa, melphalan, CY and/or TBI. EFS at 3 years for non-malignant and malignant diseases was 88% and 49%, respectively. Leukaemia patients in remission had a survival of 51% at 3 years; nonremission patients relapsed and died within 18 months. TRM and OS in the low-risk groups 0 and 1 were similar to PRST controls. TRM in the high-risk groups 2 and 3 was markedly lower (9% vs 28% and 13% vs 53%, respectively) than in the PRST group, but OS was similar. In conclusion, TREO-based conditioning regimens in children resulted in excellent engraftment and long-term survival in nonmalignant disease. In high-risk malignancy, low acute toxicity was followed by low TRM but it did not translate into increased survival. 
534 |c 2012 
700 1 |a Schulz, A.  |e VerfasserIn  |4 aut 
700 1 |a Hönig, M.  |e VerfasserIn  |4 aut 
700 1 |a Eyrich, M.  |e VerfasserIn  |4 aut 
700 1 |a Schlegel, P.-G.  |e VerfasserIn  |4 aut 
700 1 |a Holter, W.  |e VerfasserIn  |4 aut 
700 1 |a Stachel, K. D.  |e VerfasserIn  |4 aut 
700 1 |a Ehlert, K.  |e VerfasserIn  |4 aut 
700 1 |a Greil, Johann  |e VerfasserIn  |0 (DE-588)1078331979  |0 (DE-627)838332455  |0 (DE-576)450711498  |4 aut 
700 1 |a Nürnberger, W.  |e VerfasserIn  |4 aut 
700 1 |a Wößmann, W.  |e VerfasserIn  |4 aut 
700 1 |a Bader, P.  |e VerfasserIn  |4 aut 
700 1 |a Urban, C.  |e VerfasserIn  |4 aut 
700 1 |a Müller, I.  |e VerfasserIn  |4 aut 
700 1 |a Suttorp, M.  |e VerfasserIn  |4 aut 
700 1 |a Sauer, M.  |e VerfasserIn  |4 aut 
700 1 |a Gruhn, B.  |e VerfasserIn  |4 aut 
700 1 |a Meisel, R.  |e VerfasserIn  |4 aut 
700 1 |a Zimmermann, M.  |e VerfasserIn  |4 aut 
700 1 |a Sykora, Karl-Walter  |e VerfasserIn  |0 (DE-588)140301003  |0 (DE-627)616984022  |0 (DE-576)316332941  |4 aut 
773 0 8 |i Enthalten in  |t Bone marrow transplantation  |d London : Springer Nature, 1997  |g 48(2013), 4, Seite 491-501  |h Online-Ressource  |w (DE-627)320433366  |w (DE-600)2004030-1  |w (DE-576)091012996  |x 1476-5365  |7 nnas  |a Long-term follow-up of children conditioned with Treosulfan German and Austrian experience 
773 1 8 |g volume:48  |g year:2013  |g number:4  |g pages:491-501  |g extent:11  |a Long-term follow-up of children conditioned with Treosulfan German and Austrian experience 
856 4 0 |u https://doi.org/10.1038/bmt.2012.188  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.nature.com/articles/bmt2012188  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20201119 
993 |a Article 
994 |a 2013 
998 |g 1078331979  |a Greil, Johann  |m 1078331979:Greil, Johann  |d 910000  |d 910500  |d 50000  |e 910000PG1078331979  |e 910500PG1078331979  |e 50000PG1078331979  |k 0/910000/  |k 1/910000/910500/  |k 0/50000/  |p 9 
999 |a KXP-PPN1739144228  |e 3806961867 
BIB |a Y 
SER |a journal 
JSO |a {"physDesc":[{"extent":"11 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"1997-","publisher":"Springer Nature ; Macmillan ; Nature Publishing Group","dateIssuedKey":"1997","publisherPlace":"London ; Basingstoke ; London"}],"id":{"zdb":["2004030-1"],"eki":["320433366"],"issn":["1476-5365"]},"pubHistory":["Nachgewiesen 19.1997 -"],"part":{"pages":"491-501","issue":"4","year":"2013","extent":"11","text":"48(2013), 4, Seite 491-501","volume":"48"},"note":["Gesehen am 17.01.25"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Long-term follow-up of children conditioned with Treosulfan German and Austrian experienceBone marrow transplantation","language":["eng"],"recId":"320433366","title":[{"title":"Bone marrow transplantation","title_sort":"Bone marrow transplantation"}]}],"origin":[{"dateIssuedDisp":"2013","dateIssuedKey":"2013"}],"id":{"doi":["10.1038/bmt.2012.188"],"eki":["1739144228"]},"name":{"displayForm":["R Beier, A Schulz, M Hönig, M Eyrich, P-G Schlegel, W Holter, KD Stachel, K Ehlert, J Greil, W Nürnberger, W Wößmann, P Bader, C Urban, I Müller, M Suttorp, M Sauer, B Gruhn, R Meisel, M Zimmermann and K-W Sykora"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 19.11.2020","First published: 22 October 2012"],"recId":"1739144228","language":["eng"],"title":[{"title_sort":"Long-term follow-up of children conditioned with Treosulfan","title":"Long-term follow-up of children conditioned with Treosulfan","subtitle":"German and Austrian experience"}],"person":[{"roleDisplay":"VerfasserIn","display":"Beier, Rita","role":"aut","family":"Beier","given":"Rita"},{"family":"Schulz","given":"A.","roleDisplay":"VerfasserIn","display":"Schulz, A.","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Hönig, M.","role":"aut","family":"Hönig","given":"M."},{"roleDisplay":"VerfasserIn","display":"Eyrich, M.","role":"aut","family":"Eyrich","given":"M."},{"role":"aut","display":"Schlegel, P.-G.","roleDisplay":"VerfasserIn","given":"P.-G.","family":"Schlegel"},{"given":"W.","family":"Holter","role":"aut","roleDisplay":"VerfasserIn","display":"Holter, W."},{"display":"Stachel, K. D.","roleDisplay":"VerfasserIn","role":"aut","family":"Stachel","given":"K. D."},{"given":"K.","family":"Ehlert","role":"aut","roleDisplay":"VerfasserIn","display":"Ehlert, K."},{"given":"Johann","family":"Greil","role":"aut","display":"Greil, Johann","roleDisplay":"VerfasserIn"},{"family":"Nürnberger","given":"W.","display":"Nürnberger, W.","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Wößmann","given":"W.","display":"Wößmann, W.","roleDisplay":"VerfasserIn","role":"aut"},{"given":"P.","family":"Bader","role":"aut","roleDisplay":"VerfasserIn","display":"Bader, P."},{"role":"aut","display":"Urban, C.","roleDisplay":"VerfasserIn","given":"C.","family":"Urban"},{"given":"I.","family":"Müller","role":"aut","display":"Müller, I.","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Suttorp, M.","roleDisplay":"VerfasserIn","given":"M.","family":"Suttorp"},{"given":"M.","family":"Sauer","role":"aut","roleDisplay":"VerfasserIn","display":"Sauer, M."},{"display":"Gruhn, B.","roleDisplay":"VerfasserIn","role":"aut","family":"Gruhn","given":"B."},{"role":"aut","roleDisplay":"VerfasserIn","display":"Meisel, R.","given":"R.","family":"Meisel"},{"roleDisplay":"VerfasserIn","display":"Zimmermann, M.","role":"aut","family":"Zimmermann","given":"M."},{"given":"Karl-Walter","family":"Sykora","role":"aut","roleDisplay":"VerfasserIn","display":"Sykora, Karl-Walter"}]} 
SRT |a BEIERRITASLONGTERMFO2013 

Similar Items