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Successful treatment with nab-paclitaxel and gemcitabine after FOLFIRINOX failure in a patient with metastasized pancreatic adenocarcinoma

Background: Advanced pancreatic adenocarcinoma still remains associated with a desperate prognosis. Nevertheless, treatment options for patients with metastasized disease have improved considerably over the last few years. Recently, cytotoxic combination therapies such as the FOLFIRINOX regimen and...

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Bibliographic Details
Main Authors: Berger, Anne Katrin (Author) , Weber, Tim (Author) , Jäger, Dirk (Author) , Springfeld, Christoph (Author)
Format: Article (Journal)
Language:English
Published: November 20, 2013
In: Onkologie
Year: 2013, Volume: 36, Issue: 12, Pages: 763-765
ISSN:1423-0240
DOI:10.1159/000356811
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000356811
Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/356811
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Author Notes:Anne K. Berger, Tim F. Weber, Dirk Jäger, Christoph Springfeld

MARC

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520 |a Background: Advanced pancreatic adenocarcinoma still remains associated with a desperate prognosis. Nevertheless, treatment options for patients with metastasized disease have improved considerably over the last few years. Recently, cytotoxic combination therapies such as the FOLFIRINOX regimen and combined nab-paclitaxel/gemcitabine have shown improved overall survival compared to gemcitabine alone. There is still no standard of care in second-line therapy for patients with disease progression. Case Report: We report the case of a 47-year-old patient who dramatically responded to second-line treatment with nab-paclitaxel and gemcitabine after primary progression to the FOLFIRINOX protocol. Conclusion: Second-line treatment after FOLFIRINOX is feasible for patients with good performance status. Our case report supports preclinical findings that suggest that pancreatic cancer is a heterogeneous disease. Further studies that characterize possible subgroups and identify predictive molecular markers to guide therapy are warranted. 
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