Prospective randomized trial of interferon Alfa-2b and Interleukin-2 as adjuvant treatment for resected intermediate- and high-risk primary melanoma without clinically detectable node metastasis

Show other versions (10)

Purpose: Low-dose interferon alfa (IFNα) has been shown to have limited effects in the adjuvant treatment of patients with intermediate- and high-risk primary melanoma. We hypothesized that a combination regimen with low-dose interleukin-2 (IL-2) may improve survival prospects in these patients. Pat...

Full description

Saved in:

Bibliographic Details
Main Authors:	Hauschild, Axel (Author) , Schadendorf, Dirk (Author)
Format:	Article (Journal)
Language:	English
Published:	September 21, 2016
In:	Journal of clinical oncology Year: 2003, Volume: 21, Issue: 15, Pages: 2883-2888
ISSN:	1527-7755
DOI:	10.1200/JCO.2003.07.116
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1200/JCO.2003.07.116 Verlag, lizenzpflichtig, Volltext: https://ascopubs.org/doi/10.1200/JCO.2003.07.116
Author Notes:	Axel Hauschild, Michael Weichenthal, Bernd-Rüdiger Balda, Jürgen C. Becker, Helmut H. Wolff, Wolfgang Tilgen, Klaus-Werner Schulte, Johannes Ring, Dirk Schadendorf, Stephan Lischner, Günter Burg, and Reinhard Dummer

Dacarbazine, Cisplatin, and Interferon-alfa-2b with or without Interleukin-2 in metastatic melanoma: a randomized phase III trial (18951) of the European Organisation for Research... by Keilholz, Ulrich (Author) , Schadendorf, Dirk (Author) ,

in: Journal of clinical oncology, 23 (2005), 27, Seite 6747-6755

Article (Journal) Online Resource

Patterns of constitutive and IFN-γ inducible expression of HLA class II molecules in human melanoma cell lines by Rodríguez, Teresa (Author) , Méndez, Roman (Author) , Schadendorf, Dirk (Author) ,

in: Immunogenetics, 59 (2007,2) Artikelnummer 123, 11 Seiten

Verlag, lizenzpflichtig, Volltext

Article (Journal) Online Resource

Differences in global gene expression in melanoma cell lines with and without homozygous deletion of the CDKN2A locus genes by Blöthner, Sandra (Author) , Hemminki, Kari (Author) , Chen, Bowang (Author) , Ugurel, Selma (Author) , Schadendorf, Dirk (Author) , Kumar, Rajiv (Author) ,

in: Melanoma research, 16 (2006), 4, Seite 297-307

Article (Journal) Online Resource

Dose-intensified bi-weekly temozolomide in patients with asymptomatic brain metastases from malignant melanoma: a phase II DeCOG/ADO study by Schadendorf, Dirk (Author) , Ugurel, Selma (Author) , Figl, Adina (Author) ,

in: Annals of oncology, 17 (2006), 10, Seite 1592-1597

Article (Journal) Online Resource

In vitro drug sensitivity predicts response and survival after individualized sensitivity-directed chemotherapy in metastatic melanoma: a multicenter phase II trial of the Dermatol... by Ugurel, Selma (Author) , Schadendorf, Dirk (Author) , Figl, Adina (Author) , Rittgen, Werner (Author) , Delorme, Stefan (Author) ,

in: Clinical cancer research, 12 (2006), 18, Seite 5454-5463

Article (Journal) Online Resource

Tumor type M2 pyruvate kinase (TuM2-PK) as a novel plasma tumor marker in melanoma by Ugurel, Selma (Author) , Sucker, Antje (Author) , Rittgen, Werner (Author) , Schadendorf, Dirk (Author) ,

in: International journal of cancer, 117 (2005), 5, Seite 825-830

Article (Journal) Online Resource

Clinical phase II study of pegylated liposomal doxorubicin as second-line treatment in disseminated melanoma by Fink, Wolfram (Author) , Figl, Adina (Author) , Figl, Robert (Author) , Ugurel, Selma (Author) , Schadendorf, Dirk (Author) ,

in: Onkologie, 27 (2004), 6, Seite 540-544

Article (Journal) Online Resource

Down-regulation of HLA class II and costimulatory CD86/B7-2 on circulating monocytes from melanoma patients by Ugurel, Selma (Author) , Schadendorf, Dirk (Author) ,

in: Cancer immunology immunotherapy, 53 (2004), 6, Seite 551-559

Verlag, lizenzpflichtig, Volltext

Article (Journal) Online Resource

Identification of known and novel immunogenic T-cell epitopes from tumor antigens recognized by peripheral blood T cells from patients responding to IL-2-based treatment by Scheibenbogen, Carmen (Author) , Song, Mingxia (Author) , Schadendorf, Dirk (Author) ,

in: International journal of cancer, 98 (2002), 3, Seite 409-414

Article (Journal) Online Resource

Treatment of disseminated ocular melanoma with sequential fotemustine, interferon α, and interleukin 2 by Becker, Jürgen C. (Author) , Schadendorf, Dirk (Author) ,

in: British journal of cancer, 87 (2002), 8, Seite 840-845

Article (Journal) Online Resource