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Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas

Two recurrent mutations, K27M and G34R/V, within histone variant H3.3 were recently identified in ∼50% of pHGGs. Both mutations define clinically and biologically distinct subgroups of pHGGs. Here, we provide further insight about the dominant-negative effect of K27M mutant H3.3, leading to a global...

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Hauptverfasser: Bender, Sebastian (VerfasserIn) , Tang, Yujie (VerfasserIn) , Lindroth, Anders (VerfasserIn) , Hovestadt, Volker (VerfasserIn) , Jones, David T. W. (VerfasserIn) , Kool, Marcel (VerfasserIn) , Zapatka, Marc (VerfasserIn) , Northcott, Paul A. (VerfasserIn) , Sturm, Dominik (VerfasserIn) , Wei, Wang (VerfasserIn) , Radlwimmer, Bernhard (VerfasserIn) , Højfeldt, Jonas W. (VerfasserIn) , Truffaux, Nathalène (VerfasserIn) , Castel, David (VerfasserIn) , Schubert, Simone (VerfasserIn) , Ryzhova, Marina (VerfasserIn) , Şeker-Cin, Huriye (VerfasserIn) , Gronych, Jan (VerfasserIn) , Johann, Pascal-David (VerfasserIn) , Stark, Sebastian (VerfasserIn) , Meyer, Jochen (VerfasserIn) , Milde, Till (VerfasserIn) , Schuhmann, Martin (VerfasserIn) , Ebinger, Martin (VerfasserIn) , Witt, Olaf (VerfasserIn) , Deimling, Andreas von (VerfasserIn) , Korshunov, Andrey (VerfasserIn) , Lichter, Peter (VerfasserIn) , Plass, Christoph (VerfasserIn) , Pfister, Stefan (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: October 31, 2013
In: Cancer cell
Year: 2013, Jahrgang: 24, Heft: 5, Pages: 660-672
ISSN:1878-3686
DOI:10.1016/j.ccr.2013.10.006
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ccr.2013.10.006
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1535610813004558
Volltext
Verfasserangaben:Sebastian Bender, Yujie Tang, Anders M. Lindroth, Volker Hovestadt, David T.W. Jones, Marcel Kool, Marc Zapatka, Paul A. Northcott, Dominik Sturm, Wei Wang, Bernhard Radlwimmer, Jonas W. Højfeldt, Nathalène Truffaux, David Castel, Simone Schubert, Marina Ryzhova, Huriye Şeker-Cin, Jan Gronych, Pascal David Johann, Sebastian Stark, Jochen Meyer, Till Milde, Martin Schuhmann, Martin Ebinger, Camelia-Maria Monoranu, Anitha Ponnuswami, Spenser Chen, Chris Jones, Olaf Witt, V. Peter Collins, Andreas von Deimling, Nada Jabado, Stephanie Puget, Jacques Grill, Kristian Helin, Andrey Korshunov, Peter Lichter, Michelle Monje, Christoph Plass, Yoon-Jae Cho, and Stefan M. Pfister

MARC

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