Vascular endothelial growth factor receptor-3 expression predicts sentinel node status in primary cutaneous melanoma
This study analysed the expression of vascular endothelial growth factor-A (VEGF), VEGFR-2, and VEGFR-3 in primary cutaneous melanomas with positive and negative sentinel node status (SLN) (a total of 58 specimens divided into 2 groups of 29 for each status). The specimens were collected from the pa...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 3, 2020
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| In: |
Acta dermato-venereologica
Year: 2020, Jahrgang: 100, Heft: 15 |
| ISSN: | 1651-2057 |
| DOI: | 10.2340/00015555-3588 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2340/00015555-3588 Verlag, lizenzpflichtig, Volltext: https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-3588 
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| Verfasserangaben: | Ferdinand Toberer, Holger A. Haenssle, Martin Laimer, Monika Heinzel-Gutenbrunner, Alexander Enk, Wolfgang Hartschuh, Peter Helmbold and Heinz Kutzner |
MARC
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| 520 | |a This study analysed the expression of vascular endothelial growth factor-A (VEGF), VEGFR-2, and VEGFR-3 in primary cutaneous melanomas with positive and negative sentinel node status (SLN) (a total of 58 specimens divided into 2 groups of 29 for each status). The specimens were collected from the pathological archive of the department of Dermatology, Venereology and Allergology of the University Medical Center Heidelberg. A quantification score was developed for protein expression, by considering the percentage of positive melanoma cells (0: 0%, 1: up to 1%, 2: 2-10%, 3: 11-50%, and 4: 50%) in relation to the intensity of staining (0: negative, 1: low, 2: medium, 3: strong). Tumoural VEGFR-3 expression (mean +/- standard deviation) in SLN+ tumours (9.62 +/- 3.09) was significantly stronger than in SLN- tumours (6.13 +/- 3.87; p < 0.001). A binary logistic regression model proved VEGFR-3 expression and tumour thickness to be significant independent predictors of SLN. These data provide evidence that VEGFR-3 expression may play a critical role in the pathogenesis of malignant melanoma and that its investigation may help to improve the selection of patients with primary cutaneous melanoma for sentinel node biopsy. | ||
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