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Small airway dysfunction as predictor and marker for clinical response to biological therapy in severe eosinophilic asthma: a longitudinal observational study

Anti-T2 biological therapies have proven to effectively reduce acute exacerbations and daily doses of oral steroids in severe eosinophilic asthma. Despite the remarkable clinical efficacy, there are usually only moderate improvements in airflow limitation, suggesting that other measures of lung func...

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Hauptverfasser: Abdo, Mustafa (VerfasserIn) , Watz, Henrik (VerfasserIn) , Veith, Vera (VerfasserIn) , Kirsten, Anne-Marie (VerfasserIn) , Biller, Heike (VerfasserIn) , Pedersen, Frauke (VerfasserIn) , Mutius, Erika von (VerfasserIn) , Kopp, Matthias (VerfasserIn) , Hansen, Gesine (VerfasserIn) , Waschki, Benjamin (VerfasserIn) , Rabe, Klaus F. (VerfasserIn) , Trinkmann, Frederik (VerfasserIn) , Bahmer, Thomas (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 21 October 2020
In: Respiratory research
Year: 2020, Jahrgang: 21
ISSN:1465-993X
DOI:10.1186/s12931-020-01543-5
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12931-020-01543-5
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Verfasserangaben:Mustafa Abdo, Henrik Watz, Vera Veith, Anne-Marie Kirsten, Heike Biller, Frauke Pedersen, Erika von Mutius, Matthias V. Kopp, Gesine Hansen, Benjamin Waschki, Klaus F. Rabe, Frederik Trinkmann and Thomas Bahmer
Beschreibung
Zusammenfassung:Anti-T2 biological therapies have proven to effectively reduce acute exacerbations and daily doses of oral steroids in severe eosinophilic asthma. Despite the remarkable clinical efficacy, there are usually only moderate improvements in airflow limitation, suggesting that other measures of lung function like small airway dysfunction (SAD) might better reflect the clinical response. We aimed to investigate if measures of small airway function would predict and correlate with the clinical response to anti-T2 therapy.
Beschreibung:Gesehen am 26.11.2020
Beschreibung:Online Resource
ISSN:1465-993X
DOI:10.1186/s12931-020-01543-5

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