Radiosensitization by histone deacetylase inhibition in an osteosarcoma mouse model
Osteosarcomas (OS) are highly malignant and radioresistant tumors. Histone deacetylase inhibitors (HDACi) constitute a novel class of anticancer agents. We sought to investigate the effect of combined treatment with suberoylanilide hydroxamic acid (SAHA) and radiotherapy in OS in vivo.
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 June 2013
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| In: |
Strahlentherapie und Onkologie
Year: 2013, Jahrgang: 189, Heft: 11, Pages: 957-966 |
| ISSN: | 1439-099X |
| DOI: | 10.1007/s00066-013-0372-8 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00066-013-0372-8
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| Verfasserangaben: | C. Blattmann, M. Thiemann, A. Stenzinger, A. Christmann, E. Roth, V. Ehemann, J. Debus, A.E. Kulozik, W. Weichert, P.E. Huber, S. Oertel, A. Abdollahi |
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| 520 | |a Osteosarcomas (OS) are highly malignant and radioresistant tumors. Histone deacetylase inhibitors (HDACi) constitute a novel class of anticancer agents. We sought to investigate the effect of combined treatment with suberoylanilide hydroxamic acid (SAHA) and radiotherapy in OS in vivo. | ||
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