Accumulation of lipid peroxidation-derived DNA lesions: Potential lead markers for chemoprevention of inflammation-driven malignancies
Chronic inflammatory processes produce an excess of ROS and DNA-reactive aldehydes from lipid peroxidation (LPO), such as trans-4-hydroxy-2-nonenal (HNE) and malondialdehyde (MDA), which can modify cellular macromolecules and drive to malignancy. Etheno-modified DNA bases are generated inter alia by...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 August 2005
|
| In: |
Mutation research. Fundamental and molecular mechanisms of mutagenesis
Year: 2005, Jahrgang: 591, Pages: 34-44 |
| ISSN: | 1879-2871 |
| DOI: | 10.1016/j.mrfmmm.2005.04.013 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.mrfmmm.2005.04.013 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0027510705002836 
|
| Verfasserangaben: | Helmut Bartsch, Jagadeesan Nair |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1741321239 | ||
| 003 | DE-627 | ||
| 005 | 20230428021759.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201127s2005 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.mrfmmm.2005.04.013 |2 doi | |
| 035 | |a (DE-627)1741321239 | ||
| 035 | |a (DE-599)KXP1741321239 | ||
| 035 | |a (OCoLC)1341382756 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bartsch, Helmut |d 1940- |e VerfasserIn |0 (DE-588)1021102032 |0 (DE-627)691457018 |0 (DE-576)362545545 |4 aut | |
| 245 | 1 | 0 | |a Accumulation of lipid peroxidation-derived DNA lesions |b Potential lead markers for chemoprevention of inflammation-driven malignancies |c Helmut Bartsch, Jagadeesan Nair |
| 264 | 1 | |c 15 August 2005 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.11.2020 | ||
| 520 | |a Chronic inflammatory processes produce an excess of ROS and DNA-reactive aldehydes from lipid peroxidation (LPO), such as trans-4-hydroxy-2-nonenal (HNE) and malondialdehyde (MDA), which can modify cellular macromolecules and drive to malignancy. Etheno-modified DNA bases are generated inter alia by reaction of DNA with the major LPO product, HNE. We are investigating steady-state levels of etheno-DNA adducts in organs with diseases related to persistent inflammatory processes that can lead to malignancies. We have developed ultrasensitive and specific methods for the detection of etheno-DNA base adducts in human tissues and in urine. Etheno-DNA adduct levels were found to be significantly elevated in the affected organs of subjects with chronic pancreatitis, ulcerative colitis and Crohn's disease. When patients with alcohol abuse-related hepatitis, fatty liver, fibrosis and cirrhosis were compared with asymptomatic livers, excess hepatic DNA damage was seen in the three latter patient groups. Etheno-deoxyadenosine excreted in urine was measured in HBV-infected patients diagnosed with chronic hepatitis, cirrhosis and hepatocellular carcinoma. As compared to controls, these patients had up to 90-fold increased urinary levels. Impaired or imbalanced DNA-repair pathways may influence the steady-state levels of etheno-DNA adducts in inflamed tissues. In conclusion, etheno-DNA adducts may serve as potential lead markers for assessing progression of inflammatory cancer-prone diseases. If so, the efficacy of human chemopreventive interventions for malignant disease prevention could be verified. | ||
| 650 | 4 | |a 4-Hydroxy-2-nonenal | |
| 650 | 4 | |a Chronic inflammation | |
| 650 | 4 | |a Etheno-DNA adducts | |
| 650 | 4 | |a Human cancer chemoprevention | |
| 650 | 4 | |a Impaired DNA-repair | |
| 650 | 4 | |a Lipid peroxidation | |
| 700 | 1 | |a Nair, Jagadeesan |d 1953-2007 |e VerfasserIn |0 (DE-588)1221688286 |0 (DE-627)1739048865 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Mutation research. Fundamental and molecular mechanisms of mutagenesis |d Amsterdam : Elsevier, 1964 |g 591(2005), Seite 34-44 |h Online-Ressource |w (DE-627)30246607X |w (DE-600)1491099-8 |w (DE-576)079719309 |x 1879-2871 |7 nnas |a Accumulation of lipid peroxidation-derived DNA lesions Potential lead markers for chemoprevention of inflammation-driven malignancies |
| 773 | 1 | 8 | |g volume:591 |g year:2005 |g pages:34-44 |g extent:11 |a Accumulation of lipid peroxidation-derived DNA lesions Potential lead markers for chemoprevention of inflammation-driven malignancies |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.mrfmmm.2005.04.013 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0027510705002836 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201127 | ||
| 993 | |a Article | ||
| 994 | |a 2005 | ||
| 998 | |g 1221688286 |a Nair, Jagadeesan |m 1221688286:Nair, Jagadeesan |d 50000 |e 50000PN1221688286 |k 0/50000/ |p 2 |y j | ||
| 998 | |g 1021102032 |a Bartsch, Helmut |m 1021102032:Bartsch, Helmut |d 50000 |e 50000PB1021102032 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1741321239 |e 3814591925 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"recId":"30246607X","language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Accumulation of lipid peroxidation-derived DNA lesions Potential lead markers for chemoprevention of inflammation-driven malignanciesMutation research. Fundamental and molecular mechanisms of mutagenesis","note":["Gesehen am 20.02.20"],"part":{"extent":"11","volume":"591","text":"591(2005), Seite 34-44","pages":"34-44","year":"2005"},"titleAlt":[{"title":"Mutation research / Fundamental and molecular mechanisms of mutagenesis"},{"title":"MR online"},{"title":"Fundamental and molecular mechanisms of mutagenesis"},{"title":"Mutation research. Genome instability and disease"}],"pubHistory":["1.1964 -"],"title":[{"subtitle":"an international journal on mutagenesis, chromosome breakage and related subjects","title":"Mutation research","title_sort":"Mutation research","partname":"Fundamental and molecular mechanisms of mutagenesis"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1879-2871"],"zdb":["1491099-8"],"eki":["30246607X"]},"origin":[{"publisherPlace":"Amsterdam","dateIssuedDisp":"1964-","publisher":"Elsevier","dateIssuedKey":"1964"}]}],"physDesc":[{"extent":"11 S."}],"name":{"displayForm":["Helmut Bartsch, Jagadeesan Nair"]},"id":{"doi":["10.1016/j.mrfmmm.2005.04.013"],"eki":["1741321239"]},"origin":[{"dateIssuedDisp":"15 August 2005","dateIssuedKey":"2005"}],"recId":"1741321239","language":["eng"],"note":["Gesehen am 27.11.2020"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"given":"Helmut","family":"Bartsch","role":"aut","roleDisplay":"VerfasserIn","display":"Bartsch, Helmut"},{"given":"Jagadeesan","family":"Nair","role":"aut","display":"Nair, Jagadeesan","roleDisplay":"VerfasserIn"}],"title":[{"title_sort":"Accumulation of lipid peroxidation-derived DNA lesions","title":"Accumulation of lipid peroxidation-derived DNA lesions","subtitle":"Potential lead markers for chemoprevention of inflammation-driven malignancies"}]} | ||
| SRT | |a BARTSCHHELACCUMULATI1520 | ||