Short, terminally modified 2′-OMe RNAs as inhibitors of microRNA
We applied 14-mer 2′-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5′-terminus and three 2′-fluoro-2′-deoxynucleotides at the 3′-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 June 2013
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| In: |
Chemical communications
Year: 2013, Jahrgang: 49, Heft: 67, Pages: 7397-7399 |
| ISSN: | 1364-548X |
| DOI: | 10.1039/C3CC43174F |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/C3CC43174F Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2013/cc/c3cc43174f 
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| Verfasserangaben: | Jenny Blechinger, Hanna Pieper, Paul Marzenell, Larisa Kovbasyuk, Andrius Serva, Vytaute Starkuviene, Holger Erfle and Andriy Mokhir |
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| 520 | |a We applied 14-mer 2′-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5′-terminus and three 2′-fluoro-2′-deoxynucleotides at the 3′-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers. | ||
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